Development Level

Tclin 126 | 130,166
Tchem 19 | 105,938

Target Family

Ion Channel 128 | 16,788
Transporter 21 | 9,204
Enzyme 9 | 85,645
Non-IDG 9 | 16,175
GPCR 7 | 59,407
Nuclear Receptor 2 | 7,246

Target

SCN5A 33 | 327
CACNA1C 27 | 111
SCN2A 25 | 118
CACNA1D 24 | 34
SCN1A 23 | 51
SCN3A 22 | 35
SCN4A 22 | 145
SCN10A 21 | 119
SCN9A 18 | 2,970
ABCC8 16 | 21
KCNJ11 15 | 116
KCNH2 13 | 4,432
SCN8A 13 | 23
KCNA5 11 | 551
KCNA7 10 | 16
SCN11A 8 | 9
SCN7A 8 | 8
CACNA1G 6 | 240
CACNA1H 6 | 98
KCNA1 6 | 14
KCNA2 6 | 9
KCNC1 6 | 12
CACNA1F 5 | 7
CACNA1I 5 | 39
KCND3 5 | 9
SIGMAR1 5 | 1,854
CACNA1S 4 | 45
KCNA10 4 | 8
KCNA3 4 | 230
KCNA4 4 | 8
KCNC2 4 | 5
KCND2 4 | 5
KCNH1 4 | 14
KCNH5 4 | 5
TRPA1 4 | 263
CYP2D6 3 | 45
GRIN2C 3 | 10
HCN2 3 | 14
HCN4 3 | 30
KCNA6 3 | 4
KCNB1 3 | 13
KCNB2 3 | 7
KCNC3 3 | 4
KCNC4 3 | 7
KCND1 3 | 4
KCNF1 3 | 3
KCNG1 3 | 3
KCNG2 3 | 3
KCNG3 3 | 3
KCNG4 3 | 3
KCNH3 3 | 5
KCNH4 3 | 3
KCNH6 3 | 5
KCNH7 3 | 4
KCNH8 3 | 4
KCNQ1 3 | 41
KCNQ2 3 | 19
KCNQ3 3 | 7
KCNQ4 3 | 16
KCNQ5 3 | 9
KCNS1 3 | 3
KCNS2 3 | 3
KCNS3 3 | 3
KCNV1 3 | 3
KCNV2 3 | 3
SLC6A4 3 | 3,433
ADRB1 2 | 291
ASIC1 2 | 12
ASIC2 2 | 4
ASIC3 2 | 41
CA1 2 | 2,654
CA12 2 | 2,010
CA7 2 | 452
CACNA1B 2 | 201
CNGA1 2 | 4
CYP1A2 2 | 34
CYP3A4 2 | 58
DRD3 2 | 2,406
GLRA1 2 | 45
GLRB 2 | 14
GRIA4 2 | 40
GRIN1 2 | 59
GRIN2A 2 | 6
GRIN2B 2 | 119
GRIN2D 2 | 5
GRIN3A 2 | 4
GRIN3B 2 | 3
HCN1 2 | 31
HCN3 2 | 7
HRH1 2 | 553
HTR3A 2 | 432
KCNN1 2 | 20
KCNN2 2 | 26
KCNN3 2 | 35
KCNN4 2 | 54
NR3C2 2 | 175
SCNN1A 2 | 44
SCNN1B 2 | 2
SCNN1G 2 | 2
SLC29A4 2 | 9

Pharmalogical Action

BLOCKER 129 | 129
INHIBITOR 542 | 542
AGONIST 427 | 427
ANTAGONIST 350 | 350
ANTIBODY BINDING 57 | 57
POSITIVE ALLOSTERIC MODULATOR 51 | 51
ACTIVATOR 30 | 30
MODULATOR 20 | 20
OPENER 16 | 16
POSITIVE MODULATOR 15 | 15
PARTIAL AGONIST 14 | 14
INVERSE AGONIST 9 | 9
GATING INHIBITOR 6 | 6
NEGATIVE ALLOSTERIC MODULATOR 5 | 5
RELEASING AGENT 5 | 5
SUBSTRATE 5 | 5
ALLOSTERIC MODULATOR 4 | 4
PHARMACOLOGICAL CHAPERONE 3 | 3
ALLOSTERIC ANTAGONIST 2 | 2
OTHER 1 | 1

Ligand Activity

IC50 39 | 143,077
- 18 | 698
Ki 14 | 70,819
Kd 6 | 2,908
EC50 2 | 8,212

Ligand Activity Source

Guide to Pharmacology 32 | 5,022
ChEMBL 22 | 220,950

Ligand Source

CHEMBL 86 | 221,632
SCIENTIFIC LITERATURE 37 | 269
Guide to Pharmacology 32 | 5,022
IUPHAR 12 | 129
DRUG LABEL 4 | 243
KEGG DRUG 3 | 45