Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 310
Tchem 61

Target Family

GPCR 268
Ion Channel 71
Non-IDG 44
Transporter 37
Enzyme 26
Nuclear Receptor 13
Epigenetic 1

Pharmalogical Action

ANTAGONIST 310
INHIBITOR 454
AGONIST 399
BLOCKER 116
ANTIBODY BINDING 55
POSITIVE ALLOSTERIC MODULATOR 44
ACTIVATOR 27
MODULATOR 20
OPENER 17
POSITIVE MODULATOR 15
PARTIAL AGONIST 14
INVERSE AGONIST 8
RELEASING AGENT 5
SUBSTRATE 5
NEGATIVE ALLOSTERIC MODULATOR 4
NEGATIVE MODULATOR 3
ALLOSTERIC ANTAGONIST 1
OTHER 1
PHARMACOLOGICAL CHAPERONE 1

Ligand Source

CHEMBL 230
SCIENTIFIC LITERATURE 45
IUPHAR 36
DRUG LABEL 30
KEGG DRUG 15

Ligand Activity

IC50 120
Ki 109
EC50 14
Kd 12
Potency 3
AC50 2

Target

HRH1 76
DRD2 54
HTR2A 50
CHRM3 46
CHRM1 45
KCNH2 42
CHRM4 29
SIGMAR1 29
HTR2B 28
HTR2C 28
ADRA1D 27
ADRB1 27
CHRM2 27
DRD3 27
CHRM5 25
SLC6A4 25
ADRA2B 21
ADRA2C 21
ADRA1A 19
ADRB2 18
HTR6 17
ADRA1B 15
ADRA2A 15
DRD4 15
HTR1A 15
HTR3A 15
DRD1 14
HTR7 14
SLC6A3 12
AGTR1 11
CHRNA1 11
CHRNB1 11
CHRND 11
OPRM1 11
SLC6A2 11
CYP2D6 10
ADORA3 8
HRH2 8
AR 7
CYP2C19 6
H1F0 6
KCNK2 6
OPRD1 6
OPRK1 6
ADORA2A 5
ADORA2B 5
DRD5 5
HTR3B 5
TACR1 5
ADORA1 4
CYSLTR1 4
EDNRA 4
GLRA1 4
GNRHR 4
NR3C2 4
P2RY12 4
ABCB1 3
ACHE 3
AGTR2 3
AVPR2 3
HTR1B 3
PDE3A 3
PDE4A 3
PDE4B 3
PGR 3
SCN5A 3
TDP1 3
ADRB3 2
AVPR1A 2
CA12 2
CA2 2
CA5A 2
CA5B 2
CA6 2
CA7 2
CA9 2
CHRFAM7A 2
CHRNA3 2
CHRNB4 2
EBP 2
EDNRB 2
ESR1 2
ESR2 2
GABRA1 2
GABRG2 2
GFER 2
GRIA1 2
GRIA2 2
GRIA3 2
GRIA4 2
GRIN2A 2
GRIN2B 2
HRH4 2
HTR1D 2
NR3C1 2
PDE3B 2
PDE4C 2
PDE4D 2
SCN1A 2
SLC47A1 2