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Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Library

Selleck Bioactive Compound 67 | 855
Selleck FDA Approved Drug 67 | 410
NCATS MIPE 39 | 567
Selleck Target Selective Inhibitor 11 | 213

Development Level

Tclin 313 | 127,306
Tchem 67 | 103,180

Target Family

GPCR 270 | 57,167
Ion Channel 70 | 16,308
Non-IDG 45 | 16,032
Transporter 37 | 9,020
Enzyme 26 | 84,773
Nuclear Receptor 15 | 6,975
Epigenetic 1 | 4,976

Target

HRH1 75 | 485
DRD2 55 | 2,367
HTR2A 50 | 1,998
CHRM1 46 | 556
CHRM3 45 | 894
KCNH2 42 | 4,416
CHRM4 29 | 203
HTR2B 29 | 467
SIGMAR1 29 | 1,848
CHRM2 28 | 610
DRD3 28 | 2,358
HTR2C 28 | 1,154
ADRA1D 27 | 680
ADRB1 27 | 261
SLC6A4 26 | 3,404
CHRM5 25 | 127
ADRA2B 21 | 162
ADRA2C 21 | 283
HTR6 20 | 1,944
ADRA1A 19 | 1,014
ADRB2 19 | 355
DRD4 17 | 1,272
ADRA2A 16 | 366
HTR1A 16 | 2,121
HTR7 16 | 911
ADRA1B 15 | 549
DRD1 15 | 421
HTR3A 15 | 407
SLC6A2 12 | 2,194
SLC6A3 12 | 1,746
AGTR1 11 | 551
CHRNA1 11 | 20
CHRNB1 11 | 13
CHRND 11 | 18
OPRM1 11 | 1,772
CYP2D6 10 | 42
ADORA3 8 | 1,687
AR 7 | 776
HRH2 7 | 23
CYP2C19 6 | 39
H1F0 6 | 7
OPRD1 6 | 1,561
OPRK1 6 | 1,626
ADORA2A 5 | 1,511
ADORA2B 5 | 834
DRD5 5 | 92
HTR3B 5 | 6
KCNK2 5 | 18
TACR1 5 | 1,832
ADORA1 4 | 1,099
CYSLTR1 4 | 89
EDNRA 4 | 703
GLRA1 4 | 31
GNRHR 4 | 750
NR3C2 4 | 160
P2RY12 4 | 622
PGR 4 | 625
ABCB1 3 | 568
ACHE 3 | 1,867
AGTR2 3 | 255
AVPR2 3 | 301
HTR1B 3 | 515
HTR1F 3 | 93
PDE3A 3 | 129
PDE4A 3 | 512
PDE4B 3 | 804
SCN5A 3 | 316
TDP1 3 | 782
ADRB3 2 | 217
AVPR1A 2 | 395
CA12 2 | 1,996
CA2 2 | 4,179
CA5A 2 | 137
CA5B 2 | 101
CA6 2 | 98
CA7 2 | 442
CA9 2 | 2,401
CHRFAM7A 2 | 445
CHRNA3 2 | 20
CHRNB4 2 | 3
EBP 2 | 40
EDNRB 2 | 198
ESR1 2 | 944
ESR2 2 | 901
GABRA1 2 | 139
GABRG2 2 | 48
GFER 2 | 456
GRIA1 2 | 75
GRIA2 2 | 164
GRIA3 2 | 18
GRIA4 2 | 37
GRIN2A 2 | 5
GRIN2B 2 | 118
HTR1D 2 | 770
NR3C1 2 | 1,478
PDE3B 2 | 74
PDE4C 2 | 79
PDE4D 2 | 432
SCN1A 2 | 49
SLC47A1 2 | 12

Pharmalogical Action

ANTAGONIST 314 | 314
INHIBITOR 471 | 471
AGONIST 405 | 405
BLOCKER 117 | 117
ANTIBODY BINDING 57 | 57
POSITIVE ALLOSTERIC MODULATOR 41 | 41
ACTIVATOR 28 | 28
MODULATOR 19 | 19
OPENER 15 | 15
POSITIVE MODULATOR 14 | 14
PARTIAL AGONIST 12 | 12
INVERSE AGONIST 8 | 8
GATING INHIBITOR 6 | 6
RELEASING AGENT 5 | 5
SUBSTRATE 5 | 5
ALLOSTERIC MODULATOR 4 | 4
NEGATIVE ALLOSTERIC MODULATOR 4 | 4
PHARMACOLOGICAL CHAPERONE 3 | 3
ALLOSTERIC ANTAGONIST 1 | 1
OTHER 1 | 1

Ligand Activity

IC50 119 | 141,067
Ki 110 | 69,787
EC50 15 | 7,763
Kd 12 | 2,644
Potency 4 | 2,975
AC50 1 | 517

Ligand Source

CHEMBL 233 | 221,399
SCIENTIFIC LITERATURE 46 | 251
IUPHAR 40 | 121
DRUG LABEL 30 | 219
KEGG DRUG 13 | 44