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Development Level

Tclin 350 | 130,166
Tchem 77 | 105,938

Target Family

GPCR 303 | 59,407
Ion Channel 62 | 16,788
Non-IDG 34 | 16,175
Transporter 32 | 9,204
Enzyme 23 | 85,645
Nuclear Receptor 17 | 7,246

Target

HRH1 75 | 553
DRD2 61 | 2,432
HTR2A 59 | 2,122
CHRM1 47 | 640
CHRM3 44 | 950
CHRM4 32 | 263
ADRA1D 31 | 728
DRD3 31 | 2,406
HTR2C 29 | 1,221
ADRB1 28 | 291
CHRM2 28 | 688
KCNH2 28 | 4,432
CHRM5 27 | 171
ADRA1A 23 | 1,054
HTR2B 23 | 551
HTR6 23 | 2,009
HTR7 22 | 976
SIGMAR1 22 | 1,854
ADRB2 19 | 394
ADRA1B 18 | 583
ADRA2B 18 | 185
ADRA2C 18 | 306
HTR1A 18 | 2,209
SLC6A4 18 | 3,433
ADRA2A 16 | 389
DRD4 16 | 1,320
DRD1 13 | 450
HTR1B 13 | 574
SLC6A2 13 | 2,227
CHRNA1 12 | 23
HTR3A 12 | 432
OPRM1 12 | 1,833
AGTR1 11 | 563
CHRNB1 11 | 13
CHRND 11 | 18
ADORA3 10 | 1,774
HTR1D 10 | 824
HTR1E 10 | 39
HTR1F 10 | 127
OPRK1 8 | 1,683
SLC6A3 8 | 1,766
AR 7 | 796
CYP2D6 7 | 45
HRH2 7 | 43
OPRD1 7 | 1,607
ADORA2B 6 | 900
EDNRA 6 | 716
ADORA1 5 | 1,178
ADORA2A 5 | 1,585
CYP2C19 5 | 41
DRD5 5 | 116
HTR5A 5 | 122
P2RY12 5 | 641
TACR1 5 | 1,853
ADRB3 4 | 240
AVPR1A 4 | 409
CYSLTR1 4 | 105
GNRHR 4 | 760
HTR3B 4 | 6
NR3C2 4 | 175
PGR 4 | 640
ACHE 3 | 1,877
AGTR2 3 | 256
AVPR2 3 | 311
CA12 3 | 2,010
CA2 3 | 4,185
CA7 3 | 452
EDNRB 3 | 207
EPHX2 3 | 1,376
ESR1 3 | 967
ESR2 3 | 923
KCNK2 3 | 20
PDE3A 3 | 134
PDE4A 3 | 523
PDE4B 3 | 813
SCN5A 3 | 327
SLC47A1 3 | 16
ABCB1 2 | 570
AVPR1B 2 | 105
CA1 2 | 2,654
CA5A 2 | 138
CA6 2 | 99
CA9 2 | 2,402
CHRFAM7A 2 | 455
CHRNA3 2 | 22
EBP 2 | 43
ESRRA 2 | 31
GABRA1 2 | 147
GLRA1 2 | 45
GRIA4 2 | 40
GRIN2A 2 | 6
HCRTR1 2 | 542
HCRTR2 2 | 854
KCNH1 2 | 14
KCNJ6 2 | 14
NR3C1 2 | 1,509
PDE4C 2 | 87
PDE4D 2 | 442
SCN1A 2 | 51
TLR7 2 | 47

Pharmalogical Action

ANTAGONIST 350 | 350
INHIBITOR 542 | 542
AGONIST 427 | 427
BLOCKER 129 | 129
ANTIBODY BINDING 57 | 57
POSITIVE ALLOSTERIC MODULATOR 51 | 51
ACTIVATOR 30 | 30
MODULATOR 20 | 20
OPENER 16 | 16
POSITIVE MODULATOR 15 | 15
PARTIAL AGONIST 14 | 14
INVERSE AGONIST 9 | 9
GATING INHIBITOR 6 | 6
NEGATIVE ALLOSTERIC MODULATOR 5 | 5
RELEASING AGENT 5 | 5
SUBSTRATE 5 | 5
ALLOSTERIC MODULATOR 4 | 4
PHARMACOLOGICAL CHAPERONE 3 | 3
ALLOSTERIC ANTAGONIST 2 | 2
OTHER 1 | 1

Ligand Activity

Ki 128 | 70,819
IC50 100 | 143,077
- 29 | 698
EC50 11 | 8,212
Kd 8 | 2,908

Ligand Activity Source

ChEMBL 124 | 220,950
Guide to Pharmacology 86 | 5,022

Ligand Source

CHEMBL 247 | 221,632
Guide to Pharmacology 86 | 5,022
SCIENTIFIC LITERATURE 51 | 269
IUPHAR 40 | 129
DRUG LABEL 33 | 243
KEGG DRUG 13 | 45