Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 395
Tchem 76

Target Family

GPCR 209
Nuclear Receptor 152
Non-IDG 62
Enzyme 30
Ion Channel 29
Kinase 13
Transporter 13

Pharmalogical Action

AGONIST 399
INHIBITOR 454
ANTAGONIST 310
BLOCKER 116
ANTIBODY BINDING 55
POSITIVE ALLOSTERIC MODULATOR 44
ACTIVATOR 27
MODULATOR 20
OPENER 17
POSITIVE MODULATOR 15
PARTIAL AGONIST 14
INVERSE AGONIST 8
RELEASING AGENT 5
SUBSTRATE 5
NEGATIVE ALLOSTERIC MODULATOR 4
NEGATIVE MODULATOR 3
ALLOSTERIC ANTAGONIST 1
OTHER 1
PHARMACOLOGICAL CHAPERONE 1

Ligand Source

CHEMBL 279
DRUG LABEL 61
SCIENTIFIC LITERATURE 46
IUPHAR 42
KEGG DRUG 11

Ligand Activity

Ki 77
IC50 73
EC50 31
Kd 23
Potency 8

Target

NR3C1 67
OPRM1 27
ADRB2 25
ADRA2A 23
ADRA2B 21
ADRA2C 20
AR 20
PGR 19
SHBG 19
ESR1 17
DRD2 16
ADRA1D 13
DRD3 13
ADRA1A 12
HTR1D 12
ADRB1 11
HTR1B 11
HTR2A 11
HTR1A 10
ESR2 9
HTR2B 9
SERPINA6 9
VDR 9
NR3C2 8
PPARA 8
PPARG 8
SLC6A4 8
CHRM3 7
DRD1 7
DRD4 7
EPOR 7
GNRHR 7
HTR2C 7
HTR6 7
INSR 7
KCNH2 7
NISCH 7
OPRD1 7
OPRK1 7
TDP1 7
ADRA1B 6
PTGFR 6
SLC6A2 6
AVPR1A 5
CHRM2 5
CYP2D6 5
GLP1R 5
IFNAR1 5
IFNAR2 5
PTGIR 5
RARA 5
RARB 5
RARG 5
SIGMAR1 5
CHRFAM7A 4
GLRA1 4
HTR1F 4
HTR3A 4
HTR4 4
MTNR1A 4
MTNR1B 4
PTGER1 4
PTGS2 4
RXRG 4
SLC6A3 4
SSTR2 4
SSTR5 4
TAAR1 4
ADRB3 3
ALOX5 3
AVPR1B 3
AVPR2 3
CA2 3
CALCR 3
CATSPER1 3
CATSPER2 3
CATSPER3 3
CATSPER4 3
CHRM1 3
CHRM4 3
CNR1 3
CYP2C19 3
CYP3A4 3
GABBR1 3
GABBR2 3
HTR1E 3
MC2R 3
MPL 3
NR1H4 3
OXTR 3
PTGER2 3
PTGS1 3
RXRA 3
RXRB 3
SSTR1 3
SSTR3 3
THRA 3
THRB 3
HTR3C 2
HTR3E 2