Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Library

Selleck Bioactive Compound 46 | 855
Selleck FDA Approved Drug 43 | 410
NCATS MIPE 32 | 567
Selleck Target Selective Inhibitor 4 | 213
Selleck Kinase Inhibitor 1 | 230

Development Level

Tclin 399 | 127,306
Tchem 80 | 103,180

Target Family

GPCR 216 | 57,167
Nuclear Receptor 147 | 6,975
Non-IDG 64 | 16,032
Enzyme 29 | 84,773
Ion Channel 27 | 16,308
Kinase 15 | 33,162
Transporter 14 | 9,020

Target

NR3C1 63 | 1,478
OPRM1 27 | 1,772
ADRB2 25 | 355
ADRA2A 23 | 366
ADRA2B 21 | 162
ADRA2C 20 | 283
AR 20 | 776
SHBG 20 | 91
PGR 18 | 625
DRD2 17 | 2,367
ESR1 17 | 944
ADRA1D 13 | 680
DRD3 13 | 2,358
ADRA1A 12 | 1,014
HTR1D 12 | 770
HTR2A 12 | 1,998
ADRB1 11 | 261
HTR1B 11 | 515
HTR2B 11 | 467
SERPINA6 11 | 20
DRD4 10 | 1,272
HTR1A 10 | 2,121
ESR2 9 | 901
PPARA 9 | 349
VDR 9 | 104
HTR6 8 | 1,944
KCNH2 8 | 4,416
NR3C2 8 | 160
PPARG 8 | 929
SLC6A4 8 | 3,404
CHRM3 7 | 894
DRD1 7 | 421
EPOR 7 | 7
GNRHR 7 | 750
HTR2C 7 | 1,154
INSR 7 | 71
NISCH 7 | 131
OPRD1 7 | 1,561
OPRK1 7 | 1,626
TDP1 7 | 782
ADRA1B 6 | 549
GLP1R 6 | 120
PTGFR 6 | 26
SLC6A2 6 | 2,194
AVPR1A 5 | 395
CHRM2 5 | 610
CYP2D6 5 | 42
HTR1F 5 | 93
IFNAR1 5 | 5
IFNAR2 5 | 5
PTGIR 5 | 66
RARA 5 | 63
RARB 5 | 96
RARG 5 | 91
SIGMAR1 5 | 1,848
SSTR2 5 | 214
CHRFAM7A 4 | 445
GLRA1 4 | 31
HTR3A 4 | 407
HTR4 4 | 343
MTNR1A 4 | 581
MTNR1B 4 | 620
PTGER1 4 | 388
PTGS2 4 | 1,543
RXRG 4 | 63
SLC6A3 4 | 1,746
SSTR5 4 | 279
TAAR1 4 | 54
ADRB3 3 | 217
ALOX5 3 | 751
AVPR1B 3 | 101
AVPR2 3 | 301
CA2 3 | 4,179
CATSPER1 3 | 3
CATSPER2 3 | 3
CATSPER3 3 | 3
CATSPER4 3 | 3
CHRM1 3 | 556
CHRM4 3 | 203
CNR1 3 | 1,517
CYP2C19 3 | 39
CYP3A4 3 | 53
DRD5 3 | 92
GABBR1 3 | 4
GABBR2 3 | 3
HTR1E 3 | 9
MC2R 3 | 3
MPL 3 | 35
NR1H4 3 | 150
OXTR 3 | 436
PTGER2 3 | 99
PTGS1 3 | 317
PTH1R 3 | 20
RXRA 3 | 194
RXRB 3 | 62
SSTR1 3 | 68
SSTR3 3 | 228
CYP2C9 2 | 22
HRH1 2 | 485
HTR3E 2 | 2

Pharmalogical Action

AGONIST 405 | 405
INHIBITOR 471 | 471
ANTAGONIST 314 | 314
BLOCKER 117 | 117
ANTIBODY BINDING 57 | 57
POSITIVE ALLOSTERIC MODULATOR 41 | 41
ACTIVATOR 28 | 28
MODULATOR 19 | 19
OPENER 15 | 15
POSITIVE MODULATOR 14 | 14
PARTIAL AGONIST 12 | 12
INVERSE AGONIST 8 | 8
GATING INHIBITOR 6 | 6
RELEASING AGENT 5 | 5
SUBSTRATE 5 | 5
ALLOSTERIC MODULATOR 4 | 4
NEGATIVE ALLOSTERIC MODULATOR 4 | 4
PHARMACOLOGICAL CHAPERONE 3 | 3
ALLOSTERIC ANTAGONIST 1 | 1
OTHER 1 | 1

Ligand Activity

Ki 78 | 69,787
IC50 70 | 141,067
EC50 31 | 7,763
Kd 24 | 2,644
Potency 8 | 2,975

Ligand Source

CHEMBL 274 | 221,399
DRUG LABEL 68 | 219
SCIENTIFIC LITERATURE 51 | 251
IUPHAR 44 | 121
KEGG DRUG 11 | 44