Development Level

Tclin 420 | 130,166
Tchem 90 | 105,938

Target Family

GPCR 230 | 59,407
Nuclear Receptor 157 | 7,246
Non-IDG 63 | 16,175
Ion Channel 28 | 16,788
Enzyme 22 | 85,645
Kinase 15 | 33,996
Transporter 14 | 9,204

Target

NR3C1 64 | 1,509
OPRM1 28 | 1,833
ADRA2A 27 | 389
ADRA2C 24 | 306
ADRB2 24 | 394
ADRA2B 23 | 185
SHBG 22 | 100
PGR 21 | 640
AR 20 | 796
ESR1 18 | 967
DRD2 17 | 2,432
HTR1D 17 | 824
ADRA1A 16 | 1,054
HTR1A 16 | 2,209
DRD3 15 | 2,406
DRD4 15 | 1,320
HTR1B 15 | 574
ADRA1D 14 | 728
ADRB1 13 | 291
HTR2A 13 | 2,122
HTR2B 13 | 551
ESR2 10 | 923
NR3C2 10 | 175
SERPINA6 10 | 21
DRD1 9 | 450
HTR2C 9 | 1,221
PPARG 9 | 980
VDR 9 | 118
ADRA1B 8 | 583
CHRM1 8 | 640
HTR1E 8 | 39
OPRK1 8 | 1,683
PPARA 8 | 377
RARA 8 | 78
RARB 8 | 109
RARG 8 | 106
SLC6A4 8 | 3,433
CHRM2 7 | 688
CHRM3 7 | 950
EPOR 7 | 7
GNRHR 7 | 760
HTR6 7 | 2,009
INSR 7 | 78
KCNH2 7 | 4,432
NISCH 7 | 131
PTGFR 7 | 49
GLP1R 6 | 123
HTR1F 6 | 127
MTNR1B 6 | 643
OPRD1 6 | 1,607
TDP1 6 | 782
AVPR1A 5 | 409
CHRM4 5 | 263
DRD5 5 | 116
HTR4 5 | 369
IFNAR1 5 | 5
IFNAR2 5 | 5
MTNR1A 5 | 598
PTGER1 5 | 412
PTGER2 5 | 131
PTGER3 5 | 392
PTGIR 5 | 88
RXRG 5 | 66
SLC6A2 5 | 2,227
CHRM5 4 | 171
GLRA1 4 | 45
HTR5A 4 | 122
HTR7 4 | 976
PTGER4 4 | 322
RXRA 4 | 204
SLC6A3 4 | 1,766
SSTR2 4 | 215
SSTR5 4 | 280
TAAR1 4 | 60
ADORA3 3 | 1,774
ADRB3 3 | 240
AVPR1B 3 | 105
AVPR2 3 | 311
CA2 3 | 4,185
CALCR 3 | 6
CHRFAM7A 3 | 455
CNR1 3 | 1,548
CYP2C19 3 | 41
CYP2D6 3 | 45
GABBR1 3 | 10
GABBR2 3 | 4
MC2R 3 | 3
MPL 3 | 36
NR1H4 3 | 157
OXTR 3 | 452
PTGS1 3 | 342
PTGS2 3 | 1,569
PTH1R 3 | 20
RXRB 3 | 66
SIGMAR1 3 | 1,854
SSTR1 3 | 70
SSTR3 3 | 232
THRB 3 | 216
HRH1 2 | 553
HTR3A 2 | 432

Pharmalogical Action

AGONIST 427 | 427
INHIBITOR 542 | 542
ANTAGONIST 350 | 350
BLOCKER 129 | 129
ANTIBODY BINDING 57 | 57
POSITIVE ALLOSTERIC MODULATOR 51 | 51
ACTIVATOR 30 | 30
MODULATOR 20 | 20
OPENER 16 | 16
POSITIVE MODULATOR 15 | 15
PARTIAL AGONIST 14 | 14
INVERSE AGONIST 9 | 9
GATING INHIBITOR 6 | 6
NEGATIVE ALLOSTERIC MODULATOR 5 | 5
RELEASING AGENT 5 | 5
SUBSTRATE 5 | 5
ALLOSTERIC MODULATOR 4 | 4
PHARMACOLOGICAL CHAPERONE 3 | 3
ALLOSTERIC ANTAGONIST 2 | 2
OTHER 1 | 1

Ligand Activity

Ki 82 | 70,819
IC50 66 | 143,077
EC50 33 | 8,212
- 23 | 698
Kd 21 | 2,908
Potency 7 | 2,975

Ligand Activity Source

ChEMBL 124 | 220,950
Guide to Pharmacology 69 | 5,022

Ligand Source

CHEMBL 285 | 221,632
Guide to Pharmacology 69 | 5,022
DRUG LABEL 67 | 243
SCIENTIFIC LITERATURE 52 | 269
IUPHAR 40 | 129
KEGG DRUG 11 | 45