Development Level

Tclin 29 | 130,166
Tchem 8 | 105,938

Target Family

Enzyme 13 | 85,645
Ion Channel 10 | 16,788
Non-IDG 10 | 16,175
GPCR 1 | 59,407
Kinase 1 | 33,996
Nuclear Receptor 1 | 7,246

Target

GUCY1A1 5 | 5
GUCY1A2 5 | 5
GUCY1B1 5 | 6
GUCY1B2 5 | 5
CSF3R 4 | 4
PLG 4 | 280
SERPINC1 3 | 11
KCNQ2 2 | 19
KCNT2 2 | 4
PTGS2 2 | 1,569
TRPA1 2 | 263
ACHE 1 | 1,877
AKR1B10 1 | 50
CATSPER1 1 | 9
CATSPER2 1 | 8
CATSPER3 1 | 8
CATSPER4 1 | 8
CLCNKA 1 | 1
CLCNKB 1 | 1
DRD3 1 | 2,406
DRD4 1 | 1,320
HRH1 1 | 553
HTR2A 1 | 2,122
KCND3 1 | 9
KCNJ4 1 | 6
KCNN1 1 | 20
KCNN2 1 | 26
KCNN3 1 | 35
KCNN4 1 | 54
KCNQ3 1 | 7
KCNQ4 1 | 16
KCNQ5 1 | 9
KCNT1 1 | 4
NOD2 1 | 12
NR3C2 1 | 175
PAH 1 | 3
PGR 1 | 640
PRKCA 1 | 230
PRKCB 1 | 218
PRKCD 1 | 184
PRKCE 1 | 112
PRKCG 1 | 44
PRKD1 1 | 61
PTGS1 1 | 342
SCN5A 1 | 327
SERPINA6 1 | 21
SHBG 1 | 100
TRPC5 1 | 9
TRPM4 1 | 13
TRPM5 1 | 3
TRPM8 1 | 356
TTR 1 | 30

Pharmalogical Action

ACTIVATOR 30 | 30
INHIBITOR 542 | 542
AGONIST 427 | 427
ANTAGONIST 350 | 350
BLOCKER 129 | 129
ANTIBODY BINDING 57 | 57
POSITIVE ALLOSTERIC MODULATOR 51 | 51
MODULATOR 20 | 20
OPENER 16 | 16
POSITIVE MODULATOR 15 | 15
PARTIAL AGONIST 14 | 14
INVERSE AGONIST 9 | 9
GATING INHIBITOR 6 | 6
NEGATIVE ALLOSTERIC MODULATOR 5 | 5
RELEASING AGENT 5 | 5
SUBSTRATE 5 | 5
ALLOSTERIC MODULATOR 4 | 4
PHARMACOLOGICAL CHAPERONE 3 | 3
ALLOSTERIC ANTAGONIST 2 | 2
OTHER 1 | 1

Ligand Activity

EC50 8 | 8,212
- 5 | 698
IC50 2 | 143,077
Ki 2 | 70,819

Ligand Activity Source

Guide to Pharmacology 7 | 5,022
ChEMBL 3 | 220,950

Ligand Source

CHEMBL 17 | 221,632
IUPHAR 8 | 129
DRUG LABEL 7 | 243
Guide to Pharmacology 7 | 5,022
SCIENTIFIC LITERATURE 4 | 269
KEGG DRUG 1 | 45