Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 45,078
Tchem 24,073

Target Family

GPCR 35,580
Enzyme 16,547
Kinase 4,428
Ion Channel 3,691
Non-IDG 3,447
Transporter 2,672
Nuclear Receptor 1,704
Epigenetic 229
Transcription Factor 40
TF/Epigenetic 1

Pharmalogical Action

ANTAGONIST 110
AGONIST 78
INHIBITOR 75
BLOCKER 13
PARTIAL AGONIST 6
INVERSE AGONIST 5
MODULATOR 4
ACTIVATOR 3
ALLOSTERIC MODULATOR 2
POSITIVE ALLOSTERIC MODULATOR 2
ALLOSTERIC ANTAGONIST 1
GATING INHIBITOR 1
NEGATIVE ALLOSTERIC MODULATOR 1
POSITIVE MODULATOR 1

Ligand Source

CHEMBL 65,538
IUPHAR 38
SCIENTIFIC LITERATURE 33
DRUG LABEL 23
KEGG DRUG 4

Ligand Activity

Ki 65,575
IC50 134,292
EC50 7,734
Potency 2,972
Kd 2,603
AC50 517

Target

CA2 3,583
CA1 2,484
CA9 2,324
DRD3 2,303
DRD2 2,230
HRH3 2,153
F2 2,028
HTR1A 1,924
CA12 1,904
SLC6A4 1,816
HTR6 1,737
HTR2A 1,675
CNR2 1,637
OPRM1 1,610
ADORA3 1,597
KCNH2 1,531
ADORA2A 1,467
OPRK1 1,465
ALOX5AP 1,346
SIGMAR1 1,293
OPRD1 1,213
DRD4 1,151
SLC6A2 1,125
ADORA1 1,026
SLC6A3 1,009
CNR1 985
HTR2C 942
ADRA1A 930
MCHR1 888
HTR7 863
CRHR1 811
ADORA2B 795
OPRL1 745
MC4R 692
TACR1 631
CHRM3 630
ADRA1D 614
PRSS1 603
HCRTR2 589
ELANE 566
MTNR1B 558
PIK3CA 555
PTGDR2 548
ADRA1B 526
BCL2 506
HTR1D 498
CHRM2 477
TACR2 474
P2RY12 471
NR3C1 470
HRH4 461
MTNR1A 460
DPP4 448
TRPV1 445
AR 437
MAP3K14 430
HTR2B 425
ABL1 423
GABRA5 410
DRD1 402
CA14 396
CTSS 394
HRH1 392
ADAM17 389
BDKRB1 383
PLAU 383
CTSK 381
HTR1B 378
GNRHR 376
HCRTR1 376
MAP3K12 376
PDE10A 372
LRRK2 358
CA7 352
PIM1 348
CHRM1 340
HTR3A 339
CHRFAM7A 329
BACE1 328
PGR 327
OXTR 320
ADRA2A 314
CYP19A1 309
AVPR1A 297
HTR4 289
TACR3 281
MTOR 276
CALCRL 273
PARP1 261
CCKBR 258
ADRA2C 255
CTSL 250
FAAH 234
NPY5R 232
CCR3 227
ADRB2 221
PTGER4 219
CA4 208
MCL1 208
NPY1R 202