Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Library

Selleck Bioactive Compound 215 | 855
NCATS MIPE 146 | 567
Selleck FDA Approved Drug 130 | 410
Selleck Target Selective Inhibitor 43 | 213
Selleck Kinase Inhibitor 23 | 230

Development Level

Tclin 47,065 | 127,306
Tchem 26,940 | 103,180

Target Family

GPCR 35,571 | 57,167
Enzyme 20,296 | 84,773
Non-IDG 4,429 | 16,032
Kinase 4,424 | 33,162
Ion Channel 3,685 | 16,308
Transporter 2,663 | 9,020
Nuclear Receptor 1,704 | 6,975
Epigenetic 227 | 4,976
Transcription Factor 38 | 404

Target

CA2 3,583 | 4,179
CA1 2,484 | 2,641
F10 2,383 | 3,874
CA9 2,324 | 2,401
DRD3 2,303 | 2,358
DRD2 2,230 | 2,367
HRH3 2,152 | 2,231
F2 2,034 | 2,715
HTR1A 1,924 | 2,121
CA12 1,904 | 1,996
SLC6A4 1,816 | 3,404
HTR6 1,737 | 1,944
HTR2A 1,675 | 1,998
CNR2 1,637 | 1,908
OPRM1 1,610 | 1,772
ADORA3 1,597 | 1,687
KCNH2 1,533 | 4,416
ADORA2A 1,467 | 1,511
OPRK1 1,465 | 1,626
ALOX5AP 1,346 | 1,860
SIGMAR1 1,293 | 1,848
OPRD1 1,213 | 1,561
DRD4 1,151 | 1,272
SLC6A2 1,125 | 2,194
ADORA1 1,026 | 1,099
SLC6A3 1,009 | 1,746
CNR1 985 | 1,517
HTR2C 942 | 1,154
ADRA1A 930 | 1,014
MCHR1 888 | 2,026
HTR7 863 | 911
CRHR1 811 | 1,161
ADORA2B 795 | 834
OPRL1 745 | 944
MC4R 692 | 1,050
MMP2 636 | 2,243
TACR1 631 | 1,832
CHRM3 630 | 894
ADRA1D 614 | 680
PRSS1 611 | 789
HCRTR2 589 | 837
ELANE 566 | 973
MTNR1B 558 | 620
PIK3CA 555 | 1,313
PTGDR2 548 | 1,309
MMP9 536 | 1,826
ADRA1B 526 | 549
MMP3 516 | 1,342
BCL2 506 | 930
HTR1D 498 | 770
CHRM2 477 | 610
TACR2 474 | 596
P2RY12 471 | 622
NR3C1 470 | 1,478
HRH4 460 | 503
MTNR1A 460 | 581
DPP4 448 | 3,095
TRPV1 445 | 1,397
AR 437 | 776
MAP3K14 430 | 431
HTR2B 425 | 467
ABL1 423 | 613
GABRA5 410 | 472
MMP1 410 | 1,448
ADAM17 408 | 1,185
MMP8 404 | 874
DRD1 402 | 421
CA14 396 | 414
CTSS 394 | 1,561
HRH1 392 | 485
PLAU 384 | 475
BDKRB1 383 | 409
CTSK 381 | 1,395
HTR1B 378 | 515
GNRHR 376 | 750
HCRTR1 376 | 528
MAP3K12 376 | 377
PDE10A 372 | 2,698
LRRK2 358 | 455
CA7 352 | 442
PIM1 348 | 1,122
CHRM1 340 | 556
HTR3A 339 | 407
CHRFAM7A 329 | 445
BACE1 328 | 3,667
PGR 327 | 625
OXTR 320 | 436
ADRA2A 314 | 366
CYP19A1 309 | 1,134
AVPR1A 297 | 395
HTR4 288 | 343
TACR3 281 | 393
MTOR 276 | 1,724
CALCRL 273 | 407
F11 269 | 302
MMP13 261 | 2,029
PARP1 261 | 1,622
CCKBR 258 | 570
ADRA2C 255 | 283
CTSL 250 | 776

Pharmalogical Action

ANTAGONIST 110 | 314
INHIBITOR 83 | 471
AGONIST 78 | 405
BLOCKER 14 | 117
PARTIAL AGONIST 6 | 12
INVERSE AGONIST 5 | 8
MODULATOR 4 | 19
ACTIVATOR 3 | 28
ALLOSTERIC MODULATOR 2 | 4
POSITIVE ALLOSTERIC MODULATOR 2 | 41
ALLOSTERIC ANTAGONIST 1 | 1
GATING INHIBITOR 1 | 6
NEGATIVE ALLOSTERIC MODULATOR 1 | 4
POSITIVE MODULATOR 1 | 14

Ligand Activity

Ki 69,787 | 69,787
IC50 141,067 | 141,067
EC50 7,763 | 7,763
Potency 2,975 | 2,975
Kd 2,644 | 2,644
AC50 517 | 517

Ligand Source

CHEMBL 69,749 | 221,399
IUPHAR 39 | 121
SCIENTIFIC LITERATURE 34 | 251
DRUG LABEL 23 | 219
KEGG DRUG 4 | 44