Development Level

Tclin 47,756 | 130,166
Tchem 27,497 | 105,938

Target Family

GPCR 36,086 | 59,407
Enzyme 20,540 | 85,645
Kinase 4,525 | 33,996
Non-IDG 4,474 | 16,175
Ion Channel 3,755 | 16,788
Transporter 2,771 | 9,204
Nuclear Receptor 1,749 | 7,246
Epigenetic 255 | 5,140
Transcription Factor 39 | 410

Target

CA2 3,589 | 4,185
CA1 2,497 | 2,654
F10 2,387 | 3,879
DRD3 2,326 | 2,406
CA9 2,325 | 2,402
DRD2 2,268 | 2,432
HRH3 2,162 | 2,278
F2 2,039 | 2,721
HTR1A 1,949 | 2,209
CA12 1,918 | 2,010
SLC6A4 1,841 | 3,433
HTR6 1,758 | 2,009
HTR2A 1,715 | 2,122
CNR2 1,650 | 1,926
ADORA3 1,645 | 1,774
OPRM1 1,640 | 1,833
KCNH2 1,537 | 4,432
ADORA2A 1,513 | 1,585
OPRK1 1,492 | 1,683
ALOX5AP 1,346 | 1,860
SIGMAR1 1,295 | 1,854
OPRD1 1,234 | 1,607
DRD4 1,174 | 1,320
SLC6A2 1,157 | 2,227
ADORA1 1,075 | 1,178
SLC6A3 1,022 | 1,766
CNR1 1,006 | 1,548
HTR2C 959 | 1,221
ADRA1A 939 | 1,054
MCHR1 888 | 2,039
HTR7 884 | 976
ADORA2B 835 | 900
CRHR1 812 | 1,163
OPRL1 754 | 958
MC4R 692 | 1,053
TACR1 642 | 1,853
CHRM3 638 | 950
MMP2 638 | 2,249
ADRA1D 625 | 728
PRSS1 611 | 792
HCRTR2 600 | 854
ELANE 568 | 979
MTNR1B 566 | 643
PIK3CA 563 | 1,366
PTGDR2 554 | 1,332
MMP9 540 | 1,834
ADRA1B 535 | 583
MMP3 516 | 1,345
HTR1D 515 | 824
BCL2 508 | 932
CHRM2 490 | 688
NR3C1 485 | 1,509
TACR2 478 | 605
P2RY12 473 | 641
HRH4 470 | 536
MTNR1A 468 | 598
DPP4 455 | 3,107
TRPV1 447 | 1,427
AR 445 | 796
HTR2B 439 | 551
MAP3K14 431 | 434
ABL1 423 | 631
HRH1 422 | 553
GABRA5 419 | 481
DRD1 415 | 450
MMP1 411 | 1,452
ADAM17 409 | 1,190
MMP8 406 | 878
CA14 401 | 419
HTR1B 396 | 574
CTSS 395 | 1,565
HCRTR1 386 | 542
PLAU 384 | 478
BDKRB1 383 | 413
CTSK 383 | 1,400
MAP3K12 379 | 382
GNRHR 377 | 760
PDE10A 375 | 2,702
LRRK2 363 | 465
CA7 362 | 452
CHRM1 353 | 640
PIM1 351 | 1,138
HTR3A 345 | 432
BACE1 334 | 3,691
CHRFAM7A 333 | 455
PGR 332 | 640
OXTR 322 | 452
ADRA2A 320 | 389
CYP19A1 313 | 1,140
AVPR1A 300 | 409
HTR4 295 | 369
TACR3 286 | 405
MTOR 280 | 1,755
CALCRL 273 | 407
F11 269 | 303
PARP1 263 | 1,628
MMP13 262 | 2,036
ADRA2C 261 | 306
CCKBR 259 | 596
CTSL 250 | 778

Pharmalogical Action

ANTAGONIST 128 | 350
INHIBITOR 112 | 542
AGONIST 82 | 427
BLOCKER 14 | 129
PARTIAL AGONIST 9 | 14
POSITIVE ALLOSTERIC MODULATOR 9 | 51
INVERSE AGONIST 5 | 9
MODULATOR 3 | 20
ACTIVATOR 2 | 30
ALLOSTERIC ANTAGONIST 2 | 2
ALLOSTERIC MODULATOR 2 | 4
GATING INHIBITOR 1 | 6
NEGATIVE ALLOSTERIC MODULATOR 1 | 5
OPENER 1 | 16
POSITIVE MODULATOR 1 | 15

Ligand Activity

Ki 70,819 | 70,819
IC50 143,077 | 143,077
EC50 8,212 | 8,212
Potency 2,975 | 2,975
Kd 2,908 | 2,908
- 698 | 698
AC50 517 | 517
KB 17 | 17

Ligand Activity Source

ChEMBL 69,793 | 220,950
Guide to Pharmacology 1,051 | 5,022

Ligand Source

CHEMBL 69,861 | 221,632
Guide to Pharmacology 1,051 | 5,022
SCIENTIFIC LITERATURE 46 | 269
IUPHAR 40 | 129
DRUG LABEL 35 | 243
KEGG DRUG 3 | 45