Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Library

Selleck Bioactive Compound 87 | 855
NCATS MIPE 63 | 567
Selleck Kinase Inhibitor 45 | 230
Selleck FDA Approved Drug 32 | 410
Selleck Target Selective Inhibitor 17 | 213

Development Level

Tclin 1,585 | 127,306
Tchem 1,257 | 103,180

Target Family

Enzyme 777 | 84,773
Non-IDG 693 | 16,032
GPCR 549 | 57,167
Kinase 371 | 33,162
Ion Channel 145 | 16,308
Nuclear Receptor 134 | 6,975
Epigenetic 74 | 4,976
Transporter 61 | 9,020
TF/Epigenetic 9 | 98
Transcription Factor 7 | 404

Target

CA2 247 | 4,179
CA1 107 | 2,641
CA13 106 | 139
CA7 99 | 442
HSP90AA1 93 | 701
FLT3 81 | 491
SHBG 77 | 91
TBXA2R 77 | 295
AURKA 72 | 870
PARP1 72 | 1,622
CA12 70 | 1,996
HCRTR2 66 | 837
AURKB 63 | 580
HCRTR1 58 | 528
FGF2 56 | 60
KIT 46 | 334
PDE6D 45 | 46
TACR1 44 | 1,832
ADRB1 43 | 261
CSF1R 43 | 401
FGF1 42 | 43
RPA1 42 | 42
MAPK14 39 | 1,320
EPAS1 38 | 42
RARB 38 | 96
RARG 38 | 91
PDGFRB 37 | 283
BRAF 33 | 1,004
HPSE 33 | 110
CACNA1S 32 | 38
ADORA1 31 | 1,099
PDGFRA 31 | 117
HSP90AB1 30 | 335
PNP 30 | 195
RXRA 30 | 194
CA9 29 | 2,401
RARA 29 | 63
ADRB2 28 | 355
VEGFA 27 | 35
GRB2 26 | 119
HMGCR 26 | 177
CNR1 25 | 1,517
PARP2 25 | 68
ABL1 24 | 613
GABRA1 23 | 139
KDR 23 | 1,651
LGALS3 23 | 23
PIN1 23 | 69
RET 23 | 134
SSTR3 23 | 228
ABCB1 22 | 568
DDR1 21 | 44
EGFR 21 | 1,393
GABRA5 21 | 472
KCNA3 21 | 226
AURKC 20 | 25
BIRC5 20 | 20
BRD4 20 | 391
HSP90B1 20 | 58
HTR1A 20 | 2,121
OXTR 20 | 436
TKT 20 | 48
WDR5 20 | 35
CA6 19 | 98
FLT1 19 | 151
BDKRB2 18 | 310
CACNA1C 17 | 103
CHRM1 17 | 556
DRD2 17 | 2,367
GAK 17 | 17
SLC6A4 17 | 3,404
TNF 17 | 308
F2 16 | 2,715
JAK2 16 | 1,317
DDR2 15 | 32
TTR 15 | 29
XIAP 15 | 478
FLT4 14 | 83
FOLH1 14 | 191
JAK3 14 | 620
KCNH2 14 | 4,416
LCK 14 | 480
MAP3K19 14 | 15
THRB 14 | 208
BCL2L1 13 | 441
JAK1 13 | 1,067
OPRM1 13 | 1,772
PGF 13 | 17
PPIA 13 | 104
STK10 13 | 13
BCL2 12 | 930
HPGDS 12 | 77
HRH4 12 | 503
LDHA 12 | 80
MCL1 12 | 278
PTK2 12 | 304
AR 11 | 776
FKBP1A 11 | 341
HTR6 11 | 1,944
THRA 11 | 102

Pharmalogical Action

INHIBITOR 29 | 471
AGONIST 24 | 405
ANTAGONIST 12 | 314
BLOCKER 4 | 117
POSITIVE ALLOSTERIC MODULATOR 2 | 41
ACTIVATOR 1 | 28
ALLOSTERIC ANTAGONIST 1 | 1
ALLOSTERIC MODULATOR 1 | 4
GATING INHIBITOR 1 | 6
PARTIAL AGONIST 1 | 12

Ligand Activity

Kd 2,644 | 2,644
IC50 141,067 | 141,067
Ki 69,787 | 69,787
EC50 7,763 | 7,763
Potency 2,975 | 2,975
AC50 517 | 517

Ligand Source

CHEMBL 2,638 | 221,399
IUPHAR 9 | 121
DRUG LABEL 6 | 219
KEGG DRUG 5 | 44
SCIENTIFIC LITERATURE 4 | 251