Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 1,556
Tchem 1,299

Target Family

Enzyme 790
Non-IDG 705
GPCR 551
Kinase 371
Ion Channel 153
Nuclear Receptor 135
Epigenetic 76
Transporter 65
TF/Epigenetic 9
Transcription Factor 9

Pharmalogical Action

INHIBITOR 28
AGONIST 23
ANTAGONIST 12
BLOCKER 4
POSITIVE ALLOSTERIC MODULATOR 3
ACTIVATOR 1
ALLOSTERIC ANTAGONIST 1
NEGATIVE MODULATOR 1
PARTIAL AGONIST 1

Ligand Source

CHEMBL 2,642
IUPHAR 11
KEGG DRUG 5
DRUG LABEL 4
SCIENTIFIC LITERATURE 4

Ligand Activity

Kd 2,647
IC50 141,091
Ki 69,794
EC50 7,770
Potency 2,975
AC50 517

Target

CA2 247
CA1 107
CA13 106
CA7 99
HSP90AA1 93
FLT3 81
SHBG 77
TBXA2R 77
AURKA 72
PARP1 72
CA12 70
HCRTR2 66
AURKB 63
HCRTR1 58
FGF2 56
KIT 46
PDE6D 45
TACR1 44
ADRB1 43
CSF1R 43
FGF1 42
RPA1 42
MAPK14 39
EPAS1 38
RARB 38
RARG 38
PDGFRB 37
BRAF 33
CACNA1S 33
HPSE 33
ADORA1 31
PDGFRA 31
HSP90AB1 30
PNP 30
RXRA 30
CA9 29
RARA 29
ADRB2 28
VEGFA 27
GRB2 26
HMGCR 26
CNR1 25
PARP2 25
ABL1 24
GABRA1 23
KDR 23
LGALS3 23
PIN1 23
RET 23
SSTR3 23
ABCB1 22
DDR1 21
EGFR 21
GABRA5 21
KCNA3 21
AURKC 20
BIRC5 20
BRD4 20
HSP90B1 20
HTR1A 20
OXTR 20
TKT 20
WDR5 20
CA6 19
FLT1 19
BDKRB2 18
CACNA1C 17
CHRM1 17
DRD2 17
GAK 17
SLC6A4 17
TNF 17
F2 16
JAK2 16
DDR2 15
TTR 15
XIAP 15
FLT4 14
FOLH1 14
JAK3 14
KCNH2 14
LCK 14
MAP3K19 14
THRB 14
BCL2L1 13
JAK1 13
OPRM1 13
PGF 13
PPIA 13
STK10 13
BCL2 12
CREBBP 12
HPGDS 12
HRH4 12
LDHA 12
MCL1 12
PTK2 12
AR 11
FKBP1A 11
HTR6 11