Development Level

Tclin 1,752 | 130,166
Tchem 1,394 | 105,938

Target Family

Enzyme 790 | 85,645
Non-IDG 708 | 16,175
GPCR 648 | 59,407
Kinase 427 | 33,996
Ion Channel 178 | 16,788
Nuclear Receptor 142 | 7,246
Epigenetic 98 | 5,140
Transporter 82 | 9,204
TF/Epigenetic 12 | 108
Transcription Factor 10 | 410

Target

CA2 247 | 4,185
CA1 107 | 2,654
CA13 106 | 140
CA7 99 | 452
FLT3 93 | 535
HSP90AA1 93 | 705
TBXA2R 80 | 332
SHBG 77 | 100
AURKA 74 | 898
PARP1 73 | 1,628
CA12 70 | 2,010
HCRTR2 66 | 854
AURKB 65 | 605
HCRTR1 58 | 542
FGF2 56 | 60
KIT 56 | 369
CSF1R 51 | 423
PDGFRB 48 | 322
PDE6D 45 | 46
TACR1 45 | 1,853
ADRB1 43 | 291
MAPK14 43 | 1,345
FGF1 42 | 43
RPA1 42 | 42
RARB 39 | 109
RARG 39 | 106
EPAS1 38 | 42
BRAF 37 | 1,020
PDGFRA 37 | 136
CACNA1S 33 | 45
HPSE 33 | 111
ADORA1 32 | 1,178
ADRB2 31 | 394
RXRA 31 | 204
HSP90AB1 30 | 337
KDR 30 | 1,715
PNP 30 | 196
RARA 30 | 78
BRD4 29 | 421
CA9 29 | 2,402
ABL1 27 | 631
HMGCR 27 | 250
RET 27 | 152
VEGFA 27 | 35
GRB2 26 | 119
PARP2 26 | 71
CNR1 25 | 1,548
EGFR 25 | 1,445
SLC6A4 25 | 3,433
DDR1 24 | 54
GABRA1 24 | 147
CHRM1 23 | 640
FLT1 23 | 178
GABRA5 23 | 481
HTR1A 23 | 2,209
KCNA3 23 | 230
LGALS3 23 | 23
PIN1 23 | 69
SSTR3 23 | 232
ABCB1 22 | 570
OXTR 21 | 452
WDR5 21 | 36
AURKC 20 | 33
BIRC5 20 | 21
HSP90B1 20 | 59
TKT 20 | 48
CA6 19 | 99
CACNA1C 19 | 111
BDKRB2 18 | 315
DRD2 18 | 2,432
FLT4 17 | 105
GAK 17 | 23
JAK2 17 | 1,350
TNF 17 | 308
XIAP 17 | 486
DDR2 16 | 38
F2 16 | 2,721
TTR 16 | 30
JAK1 15 | 1,095
JAK3 15 | 655
KCNH2 15 | 4,432
MAP3K19 15 | 19
FOLH1 14 | 192
HRH4 14 | 536
HTR6 14 | 2,009
LCK 14 | 503
OPRM1 14 | 1,833
SLC6A2 14 | 2,227
STK10 14 | 15
THRB 14 | 216
BCL2L1 13 | 444
CREBBP 13 | 47
HTR7 13 | 976
PGF 13 | 17
PPIA 13 | 104
SLC6A3 13 | 1,766
AR 12 | 796
BCL2 12 | 932
LDHA 12 | 80
MCL1 12 | 279

Pharmalogical Action

INHIBITOR 33 | 542
AGONIST 21 | 427
ANTAGONIST 8 | 350
BLOCKER 6 | 129
POSITIVE ALLOSTERIC MODULATOR 3 | 51
GATING INHIBITOR 2 | 6
ALLOSTERIC ANTAGONIST 1 | 2
ALLOSTERIC MODULATOR 1 | 4
OPENER 1 | 16

Ligand Activity

Kd 2,908 | 2,908
IC50 143,077 | 143,077
Ki 70,819 | 70,819
EC50 8,212 | 8,212
Potency 2,975 | 2,975
- 698 | 698
AC50 517 | 517
KB 17 | 17

Ligand Activity Source

ChEMBL 2,646 | 220,950
Guide to Pharmacology 264 | 5,022

Ligand Source

CHEMBL 2,652 | 221,632
Guide to Pharmacology 264 | 5,022
IUPHAR 11 | 129
DRUG LABEL 6 | 243
KEGG DRUG 4 | 45
SCIENTIFIC LITERATURE 4 | 269