Development Level

Tclin 77,741 | 130,166
Tchem 70,580 | 105,938

Target Family

Enzyme 62,966 | 85,645
Kinase 29,123 | 33,996
GPCR 19,504 | 59,407
Ion Channel 12,921 | 16,788
Non-IDG 8,664 | 16,175
Transporter 6,213 | 9,204
Epigenetic 4,834 | 5,140
Nuclear Receptor 3,834 | 7,246
Transcription Factor 300 | 410
TF/Epigenetic 95 | 108

Target

KCNH2 3,869 | 4,432
BACE1 3,343 | 3,691
SCN9A 2,927 | 2,970
DPP4 2,663 | 3,107
HSD11B1 2,331 | 2,493
PDE10A 2,330 | 2,702
REN 2,257 | 2,303
HDAC1 2,236 | 2,280
SLC6A4 2,021 | 3,433
ACACB 1,929 | 1,930
MMP13 1,795 | 2,036
ACHE 1,706 | 1,877
KDR 1,674 | 1,715
MMP2 1,672 | 2,249
PTGS2 1,541 | 1,569
MTOR 1,528 | 1,755
F10 1,516 | 3,879
EGFR 1,420 | 1,445
MDM2 1,385 | 1,448
MMP9 1,376 | 1,834
HDAC6 1,364 | 1,390
EPHX2 1,337 | 1,376
SLC6A2 1,335 | 2,227
P2RX7 1,284 | 1,410
TACR1 1,224 | 1,853
MAPK14 1,222 | 1,345
JAK2 1,214 | 1,350
MCHR1 1,179 | 2,039
CTSS 1,172 | 1,565
PARP1 1,161 | 1,628
MET 1,136 | 1,273
MMP1 1,118 | 1,452
CCR5 1,065 | 1,197
CTSK 1,043 | 1,400
PDE5A 1,030 | 1,120
MAOB 1,002 | 1,065
SLC6A3 1,001 | 1,766
BRAF 988 | 1,020
JAK1 938 | 1,095
TRPV1 923 | 1,427
MMP3 883 | 1,345
SLC5A2 877 | 950
PIK3CA 860 | 1,366
SYK 841 | 864
CYP19A1 838 | 1,140
NR3C1 838 | 1,509
ADAM17 833 | 1,190
P2RX3 827 | 830
CHEK1 792 | 863
AURKA 790 | 898
PIM1 790 | 1,138
CCR2 765 | 843
PTGDR2 764 | 1,332
ALOX5 750 | 755
AKT1 717 | 736
ESR2 715 | 923
PDE4B 714 | 813
MAPK1 712 | 769
CYP11B2 710 | 711
FAAH 709 | 912
BCHE 708 | 816
F2 689 | 2,721
ESR1 677 | 967
IGF1R 674 | 676
SRC 664 | 675
PTGES 636 | 636
JAK3 633 | 655
SIGMAR1 630 | 1,854
SLC5A1 630 | 648
CASP3 623 | 726
MELK 619 | 620
CTSC 613 | 641
TBXAS1 609 | 612
HDAC2 603 | 645
CETP 602 | 602
CFD 600 | 600
DGAT1 592 | 612
HDAC8 590 | 622
EDNRA 563 | 716
HDAC3 563 | 594
HSP90AA1 555 | 705
PPARG 550 | 980
AURKB 544 | 605
ROCK2 544 | 609
KCNA5 542 | 551
CTSL 540 | 778
PTPN1 534 | 668
MMP8 519 | 878
PIK3CD 516 | 587
ALOX5AP 514 | 1,860
ALK 512 | 539
AGTR1 506 | 563
CDK4 497 | 505
GLS 497 | 497
LCK 493 | 503
KIF11 487 | 602
CYP11B1 484 | 486
NPY5R 478 | 706
PDE2A 474 | 484
CPT1A 472 | 472

Pharmalogical Action

INHIBITOR 251 | 542
ANTAGONIST 100 | 350
AGONIST 66 | 427
BLOCKER 39 | 129
GATING INHIBITOR 5 | 6
MODULATOR 4 | 20
PARTIAL AGONIST 4 | 14
INVERSE AGONIST 3 | 9
NEGATIVE ALLOSTERIC MODULATOR 3 | 5
ACTIVATOR 2 | 30
OPENER 2 | 16
PHARMACOLOGICAL CHAPERONE 1 | 3
POSITIVE ALLOSTERIC MODULATOR 1 | 51
POSITIVE MODULATOR 1 | 15
RELEASING AGENT 1 | 5

Ligand Activity

IC50 143,077 | 143,077
Ki 70,819 | 70,819
EC50 8,212 | 8,212
Potency 2,975 | 2,975
Kd 2,908 | 2,908
- 698 | 698
AC50 517 | 517
KB 17 | 17

Ligand Activity Source

ChEMBL 141,070 | 220,950
Guide to Pharmacology 2,033 | 5,022

Ligand Source

CHEMBL 141,103 | 221,632
Guide to Pharmacology 2,033 | 5,022
SCIENTIFIC LITERATURE 67 | 269
DRUG LABEL 53 | 243
IUPHAR 44 | 129
KEGG DRUG 8 | 45