Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 75,722
Tchem 70,497

Target Family

Enzyme 62,426
Kinase 28,403
GPCR 19,202
Ion Channel 12,817
Non-IDG 8,693
Transporter 6,148
Epigenetic 4,731
Nuclear Receptor 3,786
Transcription Factor 307
TF/Epigenetic 89

Pharmalogical Action

INHIBITOR 206
ANTAGONIST 120
AGONIST 73
BLOCKER 29
PARTIAL AGONIST 6
ACTIVATOR 5
INVERSE AGONIST 4
MODULATOR 4
NEGATIVE MODULATOR 2
NEGATIVE ALLOSTERIC MODULATOR 1
OPENER 1
PHARMACOLOGICAL CHAPERONE 1
POSITIVE ALLOSTERIC MODULATOR 1
POSITIVE MODULATOR 1
RELEASING AGENT 1

Ligand Source

CHEMBL 141,015
SCIENTIFIC LITERATURE 36
IUPHAR 20
DRUG LABEL 14
KEGG DRUG 6

Ligand Activity

IC50 141,091
Ki 69,794
EC50 7,770
Potency 2,975
Kd 2,647
AC50 517

Target

KCNH2 3,861
BACE1 3,325
SCN9A 2,921
DPP4 2,658
HSD11B1 2,329
PDE10A 2,328
REN 2,256
HDAC1 2,221
SLC6A4 2,013
ACACB 1,927
MMP13 1,789
ACHE 1,699
MMP2 1,668
KDR 1,610
F10 1,515
PTGS2 1,513
MTOR 1,500
MDM2 1,385
MMP9 1,372
EGFR 1,371
HDAC6 1,348
EPHX2 1,328
SLC6A2 1,328
P2RX7 1,277
TACR1 1,219
MAPK14 1,201
JAK2 1,182
MCHR1 1,174
CTSS 1,168
PARP1 1,158
MMP1 1,115
MET 1,114
CCR5 1,061
CTSK 1,038
PDE5A 1,018
MAOB 995
SLC6A3 992
BRAF 975
JAK1 910
TRPV1 905
MMP3 880
SLC5A2 871
CYP19A1 834
ADAM17 829
NR3C1 828
SYK 825
P2RX3 822
PIK3CA 815
PIM1 777
CHEK1 776
AURKA 766
PTGDR2 762
CCR2 759
ALOX5 745
AKT1 710
ESR2 710
PDE4B 708
CYP11B2 707
MAPK1 707
BCHE 706
FAAH 697
F2 688
ESR1 672
IGF1R 660
SRC 643
PTGES 632
SIGMAR1 628
SLC5A1 623
CASP3 621
MELK 616
CTSC 613
TBXAS1 606
CETP 602
CFD 599
JAK3 598
HDAC2 593
DGAT1 587
HDAC8 580
EDNRA 558
HSP90AA1 552
HDAC3 549
KCNA5 538
PPARG 538
CTSL 537
ROCK2 535
PTPN1 531
AURKB 521
MMP8 517
ALOX5AP 514
AGTR1 502
ALK 497
GLS 496
KIF11 486
CYP11B1 481
CDK4 478
NPY5R 478
PIK3CD 474
CPT1A 472
PDE2A 472
LCK 470