Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Library

Selleck Bioactive Compound 552 | 855
NCATS MIPE 382 | 567
Selleck FDA Approved Drug 223 | 410
Selleck Kinase Inhibitor 195 | 230
Selleck Target Selective Inhibitor 148 | 213

Development Level

Tclin 76,744 | 127,306
Tchem 69,257 | 103,180

Target Family

Enzyme 62,362 | 84,773
Kinase 28,395 | 33,162
GPCR 19,192 | 57,167
Ion Channel 12,757 | 16,308
Non-IDG 8,596 | 16,032
Transporter 6,131 | 9,020
Epigenetic 4,719 | 4,976
Nuclear Receptor 3,779 | 6,975
Transcription Factor 299 | 404
TF/Epigenetic 88 | 98

Target

KCNH2 3,861 | 4,416
BACE1 3,325 | 3,667
SCN9A 2,920 | 2,961
DPP4 2,658 | 3,095
HSD11B1 2,329 | 2,490
PDE10A 2,328 | 2,698
REN 2,256 | 2,302
HDAC1 2,221 | 2,252
SLC6A4 2,013 | 3,404
ACACB 1,927 | 1,928
MMP13 1,789 | 2,029
ACHE 1,699 | 1,867
MMP2 1,668 | 2,243
KDR 1,610 | 1,651
F10 1,515 | 3,874
PTGS2 1,513 | 1,543
MTOR 1,500 | 1,724
MDM2 1,385 | 1,448
EGFR 1,372 | 1,393
MMP9 1,372 | 1,826
HDAC6 1,348 | 1,363
EPHX2 1,328 | 1,366
SLC6A2 1,328 | 2,194
P2RX7 1,277 | 1,398
TACR1 1,219 | 1,832
MAPK14 1,201 | 1,320
JAK2 1,183 | 1,317
MCHR1 1,174 | 2,026
CTSS 1,168 | 1,561
PARP1 1,158 | 1,622
MMP1 1,115 | 1,448
MET 1,114 | 1,247
CCR5 1,061 | 1,186
CTSK 1,038 | 1,395
PDE5A 1,019 | 1,108
MAOB 996 | 1,057
SLC6A3 992 | 1,746
BRAF 975 | 1,004
JAK1 911 | 1,067
TRPV1 905 | 1,397
MMP3 880 | 1,342
SLC5A2 873 | 946
CYP19A1 835 | 1,134
ADAM17 829 | 1,185
NR3C1 828 | 1,478
SYK 825 | 848
P2RX3 822 | 822
PIK3CA 815 | 1,313
PIM1 777 | 1,122
CHEK1 776 | 847
AURKA 766 | 870
PTGDR2 762 | 1,309
CCR2 759 | 829
ALOX5 745 | 751
AKT1 710 | 725
ESR2 710 | 901
PDE4B 708 | 804
CYP11B2 707 | 707
MAPK1 707 | 761
BCHE 706 | 813
FAAH 697 | 900
F2 688 | 2,715
ESR1 672 | 944
IGF1R 660 | 662
SRC 643 | 653
PTGES 632 | 632
SIGMAR1 628 | 1,848
SLC5A1 623 | 638
CASP3 621 | 722
MELK 616 | 617
CTSC 613 | 639
TBXAS1 606 | 609
CETP 602 | 602
CFD 599 | 599
JAK3 598 | 620
HDAC2 593 | 622
DGAT1 587 | 607
HDAC8 580 | 603
EDNRA 558 | 703
HSP90AA1 552 | 701
HDAC3 549 | 567
KCNA5 538 | 542
PPARG 538 | 929
CTSL 537 | 776
ROCK2 535 | 598
PTPN1 531 | 665
AURKB 521 | 580
MMP8 517 | 874
ALOX5AP 514 | 1,860
AGTR1 502 | 551
ALK 497 | 523
GLS 496 | 496
KIF11 486 | 601
CYP11B1 481 | 483
CDK4 478 | 485
NPY5R 478 | 702
PIK3CD 474 | 539
CPT1A 472 | 472
PDE2A 472 | 482
LCK 470 | 480

Pharmalogical Action

INHIBITOR 207 | 471
ANTAGONIST 119 | 314
AGONIST 70 | 405
BLOCKER 28 | 117
PARTIAL AGONIST 6 | 12
ACTIVATOR 5 | 28
MODULATOR 5 | 19
GATING INHIBITOR 4 | 6
INVERSE AGONIST 4 | 8
NEGATIVE ALLOSTERIC MODULATOR 1 | 4
OPENER 1 | 15
PHARMACOLOGICAL CHAPERONE 1 | 3
POSITIVE ALLOSTERIC MODULATOR 1 | 41
POSITIVE MODULATOR 1 | 14
RELEASING AGENT 1 | 5

Ligand Activity

IC50 141,067 | 141,067
Ki 69,787 | 69,787
EC50 7,763 | 7,763
Potency 2,975 | 2,975
Kd 2,644 | 2,644
AC50 517 | 517

Ligand Source

CHEMBL 141,007 | 221,399
SCIENTIFIC LITERATURE 55 | 251
IUPHAR 51 | 121
DRUG LABEL 41 | 219
KEGG DRUG 10 | 44