Development Level

Tclin 4,355 | 130,166
Tchem 4,212 | 105,938

Target Family

GPCR 3,496 | 59,407
Nuclear Receptor 1,529 | 7,246
Enzyme 1,092 | 85,645
Ion Channel 828 | 16,788
Transporter 684 | 9,204
Non-IDG 468 | 16,175
Kinase 291 | 33,996
Epigenetic 74 | 5,140
Transcription Factor 71 | 410
TF/Epigenetic 3 | 108

Target

S1PR1 426 | 810
ABCB1 295 | 570
PPARG 264 | 980
GPR119 218 | 256
NR3C1 211 | 1,509
SLC6A9 206 | 512
PPARA 191 | 377
BACE1 177 | 3,691
FFAR1 168 | 241
ESR1 163 | 967
PARP1 161 | 1,628
GRM5 149 | 661
PPARD 146 | 352
GPBAR1 131 | 138
CNR2 127 | 1,926
OPRK1 125 | 1,683
OPRM1 124 | 1,833
RORC 121 | 278
NR1H4 114 | 157
OPRD1 112 | 1,607
CNR1 111 | 1,548
GRIA2 110 | 166
ADRB3 103 | 240
GPR88 103 | 103
KCNH2 97 | 4,432
KCNJ11 97 | 116
CFTR 93 | 179
ESR2 85 | 923
OXTR 85 | 452
DRD2 84 | 2,432
NOS2 84 | 411
AR 83 | 796
GRM2 82 | 129
GLP2R 81 | 82
CHRFAM7A 78 | 455
SLC5A2 72 | 950
RXRA 70 | 204
GLP1R 66 | 123
HTR2C 66 | 1,221
TOP1 66 | 142
TRPA1 65 | 263
DRD3 64 | 2,406
MAPKAPK2 63 | 193
NOTUM 63 | 63
NR1H2 63 | 302
S1PR3 63 | 228
NR1H3 60 | 255
BACE2 59 | 411
TRPV1 59 | 1,427
PTGER2 58 | 131
VDR 58 | 118
CASR 56 | 108
HTR1A 56 | 2,209
METAP1 54 | 66
MC4R 52 | 1,053
CHRM1 51 | 640
GHSR 51 | 470
AHR 50 | 58
GRM4 48 | 71
GRM1 44 | 165
HTR4 44 | 369
TLR7 44 | 47
BCL2L1 42 | 444
CASP3 42 | 726
HRH3 42 | 2,278
HTR2B 41 | 551
RARB 41 | 109
HSD11B1 40 | 2,493
HTR1D 40 | 824
S1PR5 39 | 156
DRD4 38 | 1,320
GPR55 38 | 42
RARG 37 | 106
TDP2 37 | 41
BRS3 36 | 121
FKBP1A 36 | 345
HTR2A 36 | 2,122
AVPR2 35 | 311
ADORA2A 34 | 1,585
PER2 34 | 34
ADRB1 33 | 291
MPL 33 | 36
SFRP1 33 | 68
GABRA2 32 | 139
GYS1 32 | 32
PGR 32 | 640
GABRA1 31 | 147
HDAC1 31 | 2,280
TERT 31 | 161
GCK 30 | 66
SSTR3 30 | 232
BIRC2 29 | 306
KCNQ1 29 | 41
NOS1 29 | 504
ABCG2 28 | 160
EIF4A1 28 | 29
GPR142 28 | 28
IDO1 28 | 176
SLC40A1 28 | 28
TKT 28 | 48

Pharmalogical Action

AGONIST 33 | 427
INHIBITOR 13 | 542
ANTAGONIST 11 | 350
ACTIVATOR 8 | 30
POSITIVE ALLOSTERIC MODULATOR 5 | 51
BLOCKER 2 | 129
POSITIVE MODULATOR 2 | 15
ALLOSTERIC MODULATOR 1 | 4
OPENER 1 | 16
PHARMACOLOGICAL CHAPERONE 1 | 3

Ligand Activity

EC50 8,212 | 8,212
IC50 143,077 | 143,077
Ki 70,819 | 70,819
Potency 2,975 | 2,975
Kd 2,908 | 2,908
- 698 | 698
AC50 517 | 517
KB 17 | 17

Ligand Activity Source

ChEMBL 7,770 | 220,950
Guide to Pharmacology 454 | 5,022

Ligand Source

CHEMBL 7,774 | 221,632
Guide to Pharmacology 454 | 5,022
DRUG LABEL 12 | 243
IUPHAR 12 | 129
SCIENTIFIC LITERATURE 4 | 269
KEGG DRUG 1 | 45