Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Library

Selleck Bioactive Compound 68 | 855
NCATS MIPE 48 | 567
Selleck FDA Approved Drug 32 | 410
Selleck Target Selective Inhibitor 21 | 213
Selleck Kinase Inhibitor 6 | 230

Development Level

Tclin 4,171 | 127,306
Tchem 3,886 | 103,180

Target Family

GPCR 3,192 | 57,167
Nuclear Receptor 1,490 | 6,975
Enzyme 1,083 | 84,773
Ion Channel 729 | 16,308
Transporter 680 | 9,020
Non-IDG 450 | 16,032
Kinase 286 | 33,162
Transcription Factor 72 | 404
Epigenetic 67 | 4,976
TF/Epigenetic 3 | 98

Target

S1PR1 412 | 786
ABCB1 295 | 568
PPARG 259 | 929
NR3C1 207 | 1,478
SLC6A9 205 | 500
GPR119 203 | 224
PPARA 186 | 349
BACE1 177 | 3,667
FFAR1 165 | 230
PARP1 161 | 1,622
ESR1 159 | 944
PPARD 146 | 344
GRM5 133 | 576
GPBAR1 128 | 129
CNR2 124 | 1,908
OPRK1 124 | 1,626
OPRM1 122 | 1,772
RORC 119 | 273
NR1H4 112 | 150
OPRD1 112 | 1,561
GRIA2 108 | 164
CNR1 104 | 1,517
ADRB3 101 | 217
GPR88 101 | 101
KCNH2 97 | 4,416
KCNJ11 96 | 114
CFTR 93 | 176
OXTR 85 | 436
NOS2 84 | 405
GLP2R 81 | 82
DRD2 80 | 2,367
ESR2 80 | 901
AR 78 | 776
CHRFAM7A 75 | 445
SLC5A2 72 | 946
RXRA 70 | 194
GLP1R 66 | 120
HTR2C 66 | 1,154
TOP1 66 | 142
MAPKAPK2 63 | 187
NOTUM 63 | 63
DRD3 62 | 2,358
GRM2 62 | 84
NR1H2 60 | 287
BACE2 59 | 400
NR1H3 58 | 242
VDR 58 | 104
HTR1A 56 | 2,121
CASR 55 | 93
S1PR3 55 | 214
METAP1 53 | 65
MC4R 52 | 1,050
PTGER2 52 | 99
TRPV1 52 | 1,397
AHR 50 | 56
GHSR 49 | 460
CHRM1 46 | 556
TRPA1 44 | 199
HTR4 43 | 343
BCL2L1 42 | 441
CASP3 42 | 722
HRH3 42 | 2,231
TLR7 41 | 43
HSD11B1 40 | 2,490
HTR1D 40 | 770
HTR2B 40 | 467
DRD4 37 | 1,272
GRM1 37 | 95
TDP2 37 | 41
FKBP1A 36 | 341
RARB 36 | 96
AVPR2 35 | 301
ADORA2A 34 | 1,511
ADRB1 34 | 261
HTR2A 34 | 1,998
PER2 34 | 34
SFRP1 33 | 68
GYS1 32 | 32
MPL 32 | 35
RARG 32 | 91
BRS3 31 | 108
TERT 31 | 161
GABRA2 30 | 131
SSTR3 30 | 228
BIRC2 29 | 299
GABRA1 29 | 139
GCK 29 | 65
GRM4 29 | 44
NOS1 29 | 499
ABCG2 28 | 160
EIF4A1 28 | 29
IDO1 28 | 166
KCNQ1 28 | 32
S1PR5 28 | 142
SLC40A1 28 | 28
SLC6A4 28 | 3,404
TKT 28 | 48
GPR142 27 | 27
HTR1B 27 | 515
HDAC1 26 | 2,252

Pharmalogical Action

AGONIST 31 | 405
ANTAGONIST 15 | 314
INHIBITOR 11 | 471
BLOCKER 3 | 117
POSITIVE ALLOSTERIC MODULATOR 3 | 41
ACTIVATOR 2 | 28
ALLOSTERIC MODULATOR 2 | 4
MODULATOR 1 | 19
PARTIAL AGONIST 1 | 12
PHARMACOLOGICAL CHAPERONE 1 | 3
POSITIVE MODULATOR 1 | 14

Ligand Activity

EC50 7,763 | 7,763
IC50 141,067 | 141,067
Ki 69,787 | 69,787
Potency 2,975 | 2,975
Kd 2,644 | 2,644
AC50 517 | 517

Ligand Source

CHEMBL 7,755 | 221,399
DRUG LABEL 11 | 219
IUPHAR 9 | 121
SCIENTIFIC LITERATURE 3 | 251