Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 4,159
Tchem 3,923

Target Family

GPCR 3,193
Nuclear Receptor 1,492
Enzyme 1,096
Ion Channel 740
Transporter 680
Non-IDG 470
Kinase 288
Transcription Factor 74
Epigenetic 67
TF/Epigenetic 4
oGPCR 1

Pharmalogical Action

AGONIST 31
ANTAGONIST 14
INHIBITOR 11
POSITIVE ALLOSTERIC MODULATOR 4
BLOCKER 3
POSITIVE MODULATOR 2
ACTIVATOR 1
MODULATOR 1
OPENER 1
PARTIAL AGONIST 1

Ligand Source

CHEMBL 7,762
DRUG LABEL 11
IUPHAR 11
SCIENTIFIC LITERATURE 3

Ligand Activity

EC50 7,770
IC50 141,091
Ki 69,794
Potency 2,975
Kd 2,647
AC50 517

Target

S1PR1 412
ABCB1 295
PPARG 259
NR3C1 207
SLC6A9 205
GPR119 203
PPARA 187
BACE1 177
FFAR1 165
PARP1 161
ESR1 159
PPARD 147
GRM5 133
GPBAR1 128
CNR2 124
OPRK1 124
OPRM1 122
RORC 119
NR1H4 112
OPRD1 112
GRIA2 108
CNR1 104
ADRB3 101
GPR88 101
KCNH2 97
KCNJ11 96
CFTR 93
OXTR 85
NOS2 84
GLP2R 81
DRD2 80
ESR2 80
AR 78
CHRFAM7A 75
SLC5A2 72
RXRA 70
GLP1R 66
HTR2C 66
TOP1 66
MAPKAPK2 63
NOTUM 63
DRD3 62
GRM2 62
NR1H2 60
BACE2 59
NR1H3 58
VDR 58
HTR1A 56
CASR 55
S1PR3 55
METAP1 53
MC4R 52
PTGER2 52
TRPV1 52
AHR 50
GHSR 49
CHRM1 46
TRPA1 44
HTR4 43
BCL2L1 42
CASP3 42
HRH3 42
TLR7 41
HSD11B1 40
HTR1D 40
HTR2B 40
DRD4 37
GRM1 37
TDP2 37
FKBP1A 36
RARB 36
AVPR2 35
ADORA2A 34
ADRB1 34
HTR2A 34
PER2 34
SFRP1 33
GYS1 32
MPL 32
RARG 32
BRS3 31
TERT 31
GABRA2 30
SSTR3 30
BIRC2 29
GABRA1 29
GCK 29
GRM4 29
NOS1 29
ABCG2 28
EIF4A1 28
IDO1 28
KCNQ1 28
S1PR5 28
SLC40A1 28
SLC6A4 28
TKT 28
GPR142 27
HTR1B 27
PGR 26