Development Level

Tclin 483 | 130,166
Tchem 339 | 105,938

Target Family

GPCR 460 | 59,407
Ion Channel 159 | 16,788
Nuclear Receptor 62 | 7,246
Enzyme 45 | 85,645
Non-IDG 18 | 16,175
Transporter 15 | 9,204
Kinase 8 | 33,996
Epigenetic 6 | 5,140

Target

TRPA1 43 | 263
CHRM2 32 | 688
CHRM1 28 | 640
CHRM3 22 | 950
HTR2A 21 | 2,122
CHRM4 19 | 263
HRH1 19 | 553
GPR119 18 | 256
HTR1A 18 | 2,209
ADRB2 17 | 394
CHRM5 14 | 171
HTR1B 14 | 574
HTR6 14 | 2,009
ADRA1B 13 | 583
ADRA1D 13 | 728
ADRB3 13 | 240
HTR2B 13 | 551
HTR7 13 | 976
KCNN2 13 | 26
P2RY12 13 | 641
P2RY13 13 | 15
ADRA1A 12 | 1,054
ADRB1 12 | 291
DRD2 12 | 2,432
DRD4 12 | 1,320
FPR1 12 | 18
KCNN3 12 | 35
MTNR1B 12 | 643
PPARG 12 | 980
ADORA3 11 | 1,774
CYSLTR1 11 | 105
DRD3 11 | 2,406
HTR1D 11 | 824
P2RY6 11 | 31
PTGER1 11 | 412
PTGER3 11 | 392
DRD5 10 | 116
HTR1F 10 | 127
HTR2C 10 | 1,221
KCNA7 10 | 16
KCNH2 10 | 4,432
OPRD1 10 | 1,607
OPRM1 10 | 1,833
PTGER2 10 | 131
CACNA1C 9 | 111
CASR 9 | 108
HRH3 9 | 2,278
P2RY2 9 | 20
PTGIR 9 | 88
SCN2A 9 | 118
SCN5A 9 | 327
ADORA1 8 | 1,178
DRD1 8 | 450
ESR1 8 | 967
HRH4 8 | 536
HTR1E 8 | 39
KCNN1 8 | 20
OPRK1 8 | 1,683
S1PR1 8 | 810
ADRA2B 7 | 185
ADRA2C 7 | 306
AGTR1 7 | 563
CYSLTR2 7 | 49
ESR2 7 | 923
FFAR1 7 | 241
FPR2 7 | 23
GRM6 7 | 19
KCNA1 7 | 14
KCNA5 7 | 551
KCNC1 7 | 12
KCNN4 7 | 54
P2RY1 7 | 225
PTGER4 7 | 322
PTGFR 7 | 49
S1PR3 7 | 228
TRPV1 7 | 1,427
TRPV4 7 | 55
ADORA2B 6 | 900
ADRA2A 6 | 389
CACNA1F 6 | 7
CACNA1H 6 | 98
CACNA1I 6 | 39
CACNA1S 6 | 45
FFAR4 6 | 10
GRM5 6 | 661
HRH2 6 | 43
KCNA2 6 | 9
KCNJ6 6 | 14
LPAR3 6 | 46
MTNR1A 6 | 598
NR3C1 6 | 1,509
P2RY4 6 | 27
CACNA1G 5 | 240
FFAR2 5 | 6
HTR5A 5 | 122
KCNA10 5 | 8
KCNH1 5 | 14
KCNJ4 5 | 6
NR3C2 5 | 175
PPARA 5 | 377

Pharmalogical Action

ANTAGONIST 29 | 350
AGONIST 23 | 427
BLOCKER 18 | 129
INHIBITOR 10 | 542
ACTIVATOR 5 | 30
GATING INHIBITOR 3 | 6
OPENER 2 | 16
PARTIAL AGONIST 2 | 14
INVERSE AGONIST 1 | 9
MODULATOR 1 | 20
NEGATIVE ALLOSTERIC MODULATOR 1 | 5
POSITIVE ALLOSTERIC MODULATOR 1 | 51
POSITIVE MODULATOR 1 | 15

Ligand Activity

- 698 | 698
IC50 143,077 | 143,077
Ki 70,819 | 70,819
EC50 8,212 | 8,212
Potency 2,975 | 2,975
Kd 2,908 | 2,908
AC50 517 | 517
KB 17 | 17

Ligand Activity Source

Guide to Pharmacology 698 | 5,022
ChEMBL 8 | 220,950

Ligand Source

Guide to Pharmacology 698 | 5,022
CHEMBL 75 | 221,632
IUPHAR 18 | 129
DRUG LABEL 6 | 243
SCIENTIFIC LITERATURE 6 | 269
KEGG DRUG 3 | 45