Development Level

Tchem 2 | 105,938

Target Family

Enzyme 2 | 85,645

Target

P4HA1 2 | 2
KCNH2 4,432 | 4,432
CA2 4,185 | 4,185
F10 3,879 | 3,879
BACE1 3,691 | 3,691
SLC6A4 3,433 | 3,433
DPP4 3,107 | 3,107
SCN9A 2,970 | 2,970
F2 2,721 | 2,721
PDE10A 2,702 | 2,702
CA1 2,654 | 2,654
HSD11B1 2,493 | 2,493
DRD2 2,432 | 2,432
DRD3 2,406 | 2,406
CA9 2,402 | 2,402
REN 2,303 | 2,303
MAPT 2,286 | 2,286
HDAC1 2,280 | 2,280
HRH3 2,278 | 2,278
MMP2 2,249 | 2,249
SLC6A2 2,227 | 2,227
HTR1A 2,209 | 2,209
HTR2A 2,122 | 2,122
MCHR1 2,039 | 2,039
MMP13 2,036 | 2,036
CA12 2,010 | 2,010
HTR6 2,009 | 2,009
ACACB 1,930 | 1,930
CNR2 1,926 | 1,926
ACHE 1,877 | 1,877
ALOX5AP 1,860 | 1,860
SIGMAR1 1,854 | 1,854
TACR1 1,853 | 1,853
MMP9 1,834 | 1,834
OPRM1 1,833 | 1,833
ADORA3 1,774 | 1,774
SLC6A3 1,766 | 1,766
MTOR 1,755 | 1,755
KDR 1,715 | 1,715
OPRK1 1,683 | 1,683
PARP1 1,628 | 1,628
OPRD1 1,607 | 1,607
ADORA2A 1,585 | 1,585
PTGS2 1,569 | 1,569
CTSS 1,565 | 1,565
CNR1 1,548 | 1,548
NR3C1 1,509 | 1,509
MMP1 1,452 | 1,452
MDM2 1,448 | 1,448
EGFR 1,445 | 1,445
TRPV1 1,427 | 1,427
P2RX7 1,410 | 1,410
CTSK 1,400 | 1,400
HDAC6 1,390 | 1,390
EPHX2 1,376 | 1,376
PIK3CA 1,366 | 1,366
JAK2 1,350 | 1,350
MAPK14 1,345 | 1,345
MMP3 1,345 | 1,345
PTGDR2 1,332 | 1,332
DRD4 1,320 | 1,320
MET 1,273 | 1,273
HTR2C 1,221 | 1,221
CCR5 1,197 | 1,197
ADAM17 1,190 | 1,190
ADORA1 1,178 | 1,178
CRHR1 1,163 | 1,163
CYP19A1 1,140 | 1,140
PIM1 1,138 | 1,138
PDE5A 1,120 | 1,120
JAK1 1,095 | 1,095
MAOB 1,065 | 1,065
ADRA1A 1,054 | 1,054
MC4R 1,053 | 1,053
BRAF 1,020 | 1,020
PPARG 980 | 980
ELANE 979 | 979
HTR7 976 | 976
ESR1 967 | 967
OPRL1 958 | 958
CHRM3 950 | 950
SLC5A2 950 | 950
BCL2 932 | 932
ESR2 923 | 923
FAAH 912 | 912
ADORA2B 900 | 900
AURKA 898 | 898
MMP8 878 | 878
SYK 864 | 864
CHEK1 863 | 863
HCRTR2 854 | 854
CCR2 843 | 843
P2RX3 830 | 830
HTR1D 824 | 824
BCHE 816 | 816
PDE4B 813 | 813
S1PR1 810 | 810
AR 796 | 796
PRSS1 792 | 792
TDP1 782 | 782
CTSL 778 | 778

Ligand Activity

IC50 1 | 143,077
Ki 1 | 70,819

Ligand Activity Source

ChEMBL 2 | 220,950

Ligand Source

CHEMBL 2 | 221,632