Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 241
Tchem 29

Target Family

GPCR 83
Enzyme 66
Ion Channel 61
Non-IDG 35
Transporter 30
Kinase 14
Nuclear Receptor 6
Epigenetic 2

Pharmalogical Action

INHIBITOR 91
AGONIST 46
ANTAGONIST 45
BLOCKER 37
MODULATOR 8
OPENER 7
ANTIBODY BINDING 5
INVERSE AGONIST 4
ACTIVATOR 3
NEGATIVE MODULATOR 2
PARTIAL AGONIST 2
POSITIVE ALLOSTERIC MODULATOR 2
NEGATIVE ALLOSTERIC MODULATOR 1

Ligand Source

SCIENTIFIC LITERATURE 242
CHEMBL 33
IUPHAR 8
DRUG LABEL 6

Ligand Activity

IC50 55
Ki 34
Kd 4
EC50 3
Potency 1

Target

KCNH2 16
CACNA1C 15
CACNA1D 14
KCNJ11 12
ABCC8 11
HRH1 11
TUBB 8
TUBB1 8
TUBB2A 8
TUBB2B 8
TUBB3 8
TUBB4A 8
TUBB4B 8
TUBB6 8
TUBB8 8
ADRB1 7
DRD2 7
DRD3 7
HTR2A 7
PTGS2 7
SLC6A4 7
ACE 6
ADRA1A 5
DPP4 5
HTR3A 5
MAOA 5
ADRA2C 4
ADRB2 4
ATP4A 4
ATP4B 4
CACNA1H 4
CYP19A1 4
CYP3A4 4
DRD4 4
HTR1A 4
HTR1B 4
MAOB 4
OPRM1 4
PTGS1 4
SIGMAR1 4
SLC5A2 4
ABCB1 3
ADRA1D 3
ADRA2B 3
CACNA1F 3
CACNA1S 3
CACNA2D1 3
CACNA2D2 3
CHRM3 3
CRBN 3
EGFR 3
HRH2 3
HTR1D 3
KCNA5 3
PPARA 3
SLC6A2 3
SLC6A3 3
TAAR1 3
TRPA1 3
ABL1 2
ACHE 2
ADRA1B 2
ADRA2A 2
AKR1B1 2
AKR1B10 2
AVPR1A 2
CACNA1B 2
CACNA1G 2
CACNA1I 2
CHRM1 2
CHRM2 2
CHRNE 2
CYP11B1 2
CYP11B2 2
CYP24A1 2
CYP2C9 2
CYP2D6 2
CYSLTR1 2
DPP8 2
DRD1 2
HCAR2 2
HDAC1 2
HDAC10 2
HDAC2 2
HDAC3 2
HTR7 2
INSR 2
KCNA3 2
KCNN4 2
KDR 2
MAP2K1 2
PARP1 2
PARP2 2
PDE5A 2
PPARG 2
ROCK1 2
ROCK2 2
SCN4A 2
TACR1 2
TRPV1 2