Development Level

Tclin 268 | 130,166
Tchem 42 | 105,938

Target Family

GPCR 92 | 59,407
Enzyme 72 | 85,645
Ion Channel 62 | 16,788
Non-IDG 35 | 16,175
Transporter 28 | 9,204
Kinase 19 | 33,996
Nuclear Receptor 9 | 7,246
Epigenetic 2 | 5,140

Target

CACNA1C 14 | 111
CACNA1D 12 | 34
KCNJ11 12 | 116
ABCC8 11 | 21
DRD2 11 | 2,432
HRH1 11 | 553
KCNH2 11 | 4,432
TUBB 10 | 14
DRD3 9 | 2,406
PTGS2 9 | 1,569
HTR2A 8 | 2,122
TUBB1 8 | 31
TUBB2A 8 | 11
TUBB2B 8 | 11
TUBB3 8 | 18
TUBB4A 8 | 11
TUBB4B 8 | 11
TUBB6 8 | 11
TUBB8 8 | 11
ADRB1 7 | 291
DPP4 7 | 3,107
HTR1A 7 | 2,209
ACE 6 | 334
ADRA2C 6 | 306
DRD4 6 | 1,320
ADRA1A 5 | 1,054
HTR1D 5 | 824
HTR3A 5 | 432
MAOA 5 | 467
PTGS1 5 | 342
ADRA1D 4 | 728
ADRA2A 4 | 389
ADRA2B 4 | 185
ADRB2 4 | 394
ATP4A 4 | 10
ATP4B 4 | 10
CHRM1 4 | 640
CHRM2 4 | 688
EGFR 4 | 1,445
HTR1B 4 | 574
INSR 4 | 78
KCNA5 4 | 551
MAOB 4 | 1,065
OPRM1 4 | 1,833
PARP1 4 | 1,628
PPARA 4 | 377
SLC5A2 4 | 950
SLC6A4 4 | 3,433
ADRA1B 3 | 583
ALK 3 | 539
AVPR1A 3 | 409
CACNA1H 3 | 98
CACNA2D1 3 | 152
CACNA2D2 3 | 28
CHRM3 3 | 950
CRBN 3 | 3
CYP3A4 3 | 58
DPP8 3 | 284
DPP9 3 | 217
HRH2 3 | 43
HTR2B 3 | 551
HTR6 3 | 2,009
HTR7 3 | 976
IGF1R 3 | 676
KCNH1 3 | 14
KDR 3 | 1,715
PARP2 3 | 71
ROCK1 3 | 132
SLC5A1 3 | 648
SLC6A2 3 | 2,227
SLC6A3 3 | 1,766
TAAR1 3 | 60
TRPA1 3 | 263
ABL1 2 | 631
ACHE 2 | 1,877
AVPR1B 2 | 105
CHRM4 2 | 263
CHRM5 2 | 171
CHRNE 2 | 5
CLK1 2 | 48
CYP11B2 2 | 711
CYP19A1 2 | 1,140
CYP2C9 2 | 24
CYP2D6 2 | 45
ESR2 2 | 923
FLT3 2 | 535
FLT4 2 | 105
GRK4 2 | 4
HDAC10 2 | 186
HDAC2 2 | 645
HDAC3 2 | 594
KCNA10 2 | 8
KIT 2 | 369
LCK 2 | 503
PDGFRB 2 | 322
PIK3CD 2 | 587
PIK3CG 2 | 379
SCN4A 2 | 145
STK16 2 | 9
TRPV1 2 | 1,427

Pharmalogical Action

INHIBITOR 106 | 542
AGONIST 52 | 427
ANTAGONIST 51 | 350
BLOCKER 37 | 129
MODULATOR 8 | 20
OPENER 6 | 16
ACTIVATOR 4 | 30
ANTIBODY BINDING 4 | 57
INVERSE AGONIST 4 | 9
GATING INHIBITOR 2 | 6
POSITIVE ALLOSTERIC MODULATOR 2 | 51
NEGATIVE ALLOSTERIC MODULATOR 1 | 5
PARTIAL AGONIST 1 | 14

Ligand Activity

IC50 67 | 143,077
Ki 46 | 70,819
- 6 | 698
EC50 4 | 8,212
Kd 4 | 2,908
Potency 1 | 2,975

Ligand Activity Source

ChEMBL 69 | 220,950
Guide to Pharmacology 51 | 5,022

Ligand Source

SCIENTIFIC LITERATURE 269 | 269
Guide to Pharmacology 51 | 5,022
CHEMBL 29 | 221,632
DRUG LABEL 9 | 243
IUPHAR 4 | 129