Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 241
Tchem 28

Target Family

GPCR 85
Enzyme 60
Ion Channel 60
Non-IDG 33
Transporter 31
Kinase 16
Nuclear Receptor 7
Epigenetic 2

Pharmalogical Action

INHIBITOR 89
AGONIST 51
ANTAGONIST 46
BLOCKER 36
MODULATOR 8
OPENER 6
ACTIVATOR 4
ANTIBODY BINDING 4
INVERSE AGONIST 4
GATING INHIBITOR 3
POSITIVE ALLOSTERIC MODULATOR 2
NEGATIVE ALLOSTERIC MODULATOR 1
PARTIAL AGONIST 1

Ligand Source

SCIENTIFIC LITERATURE 242
CHEMBL 34
DRUG LABEL 10
IUPHAR 6

Ligand Activity

IC50 55
Ki 33
Kd 4
EC50 3
Potency 1

Target

KCNH2 15
CACNA1C 14
CACNA1D 13
KCNJ11 12
ABCC8 11
HRH1 11
PTGS2 9
DRD2 8
HTR2A 8
TUBB 8
TUBB1 8
TUBB2A 8
TUBB2B 8
TUBB3 8
TUBB4A 8
TUBB4B 8
TUBB6 8
TUBB8 8
ADRB1 7
DPP4 6
DRD3 6
SLC6A4 6
ADRA1A 5
DRD4 5
HTR1A 5
HTR3A 5
MAOA 5
ADRA2C 4
ADRB2 4
ATP4A 4
ATP4B 4
CYP3A4 4
HTR1B 4
MAOB 4
OPRM1 4
PPARA 4
PTGS1 4
SIGMAR1 4
SLC5A2 4
ABCB1 3
ADRA1D 3
ADRA2B 3
CACNA1F 3
CACNA1H 3
CACNA2D1 3
CACNA2D2 3
CHRM1 3
CHRM2 3
CHRM3 3
CRBN 3
CYP19A1 3
EGFR 3
HRH2 3
HTR1D 3
KCNA5 3
SLC6A2 3
SLC6A3 3
TAAR1 3
TRPA1 3
ABL1 2
ACHE 2
ADRA1B 2
ADRA2A 2
AKR1B10 2
ALK 2
AVPR1A 2
BTK 2
CACNA1B 2
CACNA1G 2
CACNA1I 2
CHRNE 2
CYP11B1 2
CYP11B2 2
CYP2C9 2
CYP2D6 2
CYSLTR1 2
DPP8 2
DRD1 2
FLT3 2
HCAR2 2
HDAC10 2
HDAC2 2
HDAC3 2
HTR6 2
HTR7 2
IGF1R 2
INSR 2
KCNN4 2
KDR 2
MAP2K1 2
PARP1 2
PDE5A 2
PIK3CD 2
PPARG 2
PTGFR 2
ROCK1 2
ROCK2 2
SCN4A 2
TACR1 2
TRPV1 2