Development Level

Tclin 45 | 130,166
Tchem 6 | 105,938

Target Family

GPCR 17 | 59,407
Enzyme 12 | 85,645
Nuclear Receptor 8 | 7,246
Ion Channel 6 | 16,788
Transporter 4 | 9,204
Non-IDG 3 | 16,175

Target

PTGS1 7 | 342
PTGS2 7 | 1,569
HRH1 4 | 553
NR3C1 4 | 1,509
ADRA1A 3 | 1,054
ADRA1B 3 | 583
CACNA1C 3 | 111
CACNA1D 3 | 34
DRD2 3 | 2,432
ADRA1D 2 | 728
ADRB1 2 | 291
CHRM1 2 | 640
CHRM2 2 | 688
CHRM3 2 | 950
GABRA1 2 | 147
GABRB2 2 | 37
GABRG2 2 | 48
SHBG 2 | 100
SLC12A1 2 | 8
SLC6A2 2 | 2,227
VDR 2 | 118
ACE 1 | 334
ACHE 1 | 1,877
ADRB2 1 | 394
AKR1B10 1 | 50
ALOX5 1 | 755
AR 1 | 796
CHRM4 1 | 263
CHRM5 1 | 171
DHFR 1 | 514
DRD1 1 | 450
DRD3 1 | 2,406
DRD4 1 | 1,320
DRD5 1 | 116
ECE1 1 | 259
GABRA2 1 | 139
GABRA3 1 | 68
GABRA4 1 | 21
GABRA5 1 | 481
GABRA6 1 | 25
GABRB1 1 | 14
GABRB3 1 | 53
GABRD 1 | 13
GABRG1 1 | 13
GABRG3 1 | 17
HSD11B1 1 | 2,493
HTR1B 1 | 574
HTR2A 1 | 2,122
HTR2B 1 | 551
HTR6 1 | 2,009
HTR7 1 | 976
KCNT2 1 | 4
MME 1 | 306
OPRM1 1 | 1,833
PGR 1 | 640
PTGDR2 1 | 1,332
PTGER1 1 | 412
PTGER2 1 | 131
SERPINA6 1 | 21
SIGMAR1 1 | 1,854
SLC12A2 1 | 3
SLC6A3 1 | 1,766
TBXA2R 1 | 332
TRPA1 1 | 263
TRPM4 1 | 13
TRPM5 1 | 3

Pharmalogical Action

INHIBITOR 15 | 542
ANTAGONIST 13 | 350
AGONIST 11 | 427
BLOCKER 3 | 129
POSITIVE ALLOSTERIC MODULATOR 2 | 51
ACTIVATOR 1 | 30
INVERSE AGONIST 1 | 9

Ligand Activity

IC50 8 | 143,077
Kd 4 | 2,908
- 3 | 698
Ki 3 | 70,819
EC50 1 | 8,212

Ligand Activity Source

ChEMBL 12 | 220,950
Guide to Pharmacology 4 | 5,022

Ligand Source

KEGG DRUG 45 | 45
CHEMBL 7 | 221,632
Guide to Pharmacology 4 | 5,022
IUPHAR 2 | 129