Development Level

Tclin 116 | 130,166
Tchem 80 | 105,938

Target Family

GPCR 70 | 59,407
Ion Channel 34 | 16,788
Enzyme 23 | 85,645
Transporter 23 | 9,204
Non-IDG 17 | 16,175
Nuclear Receptor 12 | 7,246
Kinase 4 | 33,996

Target

HTR2A 18 | 2,122
DRD3 17 | 2,406
DRD2 16 | 2,432
HTR2B 14 | 551
HTR2C 13 | 1,221
DRD4 12 | 1,320
SLC6A2 12 | 2,227
HTR1B 11 | 574
HTR1D 11 | 824
HTR7 11 | 976
SLC6A4 10 | 3,433
ADRA2B 9 | 185
ADRA2C 9 | 306
HTR1E 9 | 39
HTR1F 9 | 127
HTR6 9 | 2,009
ADRA2A 8 | 389
DRD1 8 | 450
HRH1 8 | 553
HTR1A 8 | 2,209
KCNH2 8 | 4,432
SIGMAR1 6 | 1,854
ADRA1A 5 | 1,054
ADRA1D 5 | 728
ADRB2 5 | 394
CACNA1C 5 | 111
CHRM1 5 | 640
CHRM2 5 | 688
CHRM3 5 | 950
CHRM4 5 | 263
CHRM5 5 | 171
DRD5 5 | 116
SLC6A3 5 | 1,766
ACHE 4 | 1,877
ADRB1 4 | 291
CACNA1S 4 | 45
HTR5A 4 | 122
SHBG 4 | 100
ADORA3 3 | 1,774
AR 3 | 796
BCHE 3 | 816
CACNA1D 3 | 34
CACNA1F 3 | 7
CHRFAM7A 3 | 455
GABRA1 3 | 147
GLRA1 3 | 45
GLRA2 3 | 24
GLRB 3 | 14
NR3C2 3 | 175
PGR 3 | 640
PTGS2 3 | 1,569
SERPINA6 3 | 21
TRPA1 3 | 263
ABL1 2 | 631
ACE 2 | 334
ADRA1B 2 | 583
CDK19 2 | 10
CMA1 2 | 351
CNGA1 2 | 4
CTSA 2 | 190
CTSS 2 | 1,565
ESR1 2 | 967
ESR2 2 | 923
GABRA2 2 | 139
GABRA3 2 | 68
GABRA5 2 | 481
GLRA3 2 | 12
GPR17 2 | 13
HTR3A 2 | 432
KCNA7 2 | 16
KCNJ6 2 | 14
KCNN1 2 | 20
KCNN2 2 | 26
KCNN3 2 | 35
KCNN4 2 | 54
KCNT2 2 | 4
MC3R 2 | 81
NQO2 2 | 141
P2RX4 2 | 9
P2RY12 2 | 641
PRSS1 2 | 792
RET 2 | 152
SLCO1B3 2 | 5
TRPC5 2 | 9
TRPM4 2 | 13
BDKRB1 1 | 413
C1S 1 | 77
CNGA2 1 | 3
CYP2C19 1 | 41
EBP 1 | 43
ELANE 1 | 979
FKBP1B 1 | 9
GRM8 1 | 18
KCNA10 1 | 8
KCNT1 1 | 4
KIT 1 | 369
MAOA 1 | 467
MC4R 1 | 1,053
PRKCD 1 | 184
RORB 1 | 6

Pharmalogical Action

AGONIST 40 | 427
ANTAGONIST 40 | 350
INHIBITOR 32 | 542
BLOCKER 12 | 129
ACTIVATOR 8 | 30
ALLOSTERIC MODULATOR 4 | 4
GATING INHIBITOR 4 | 6
ANTIBODY BINDING 1 | 57
INVERSE AGONIST 1 | 9
MODULATOR 1 | 20
POSITIVE ALLOSTERIC MODULATOR 1 | 51

Ligand Activity

IC50 44 | 143,077
Ki 40 | 70,819
- 18 | 698
EC50 12 | 8,212
Kd 11 | 2,908
Potency 1 | 2,975

Ligand Activity Source

Guide to Pharmacology 53 | 5,022
ChEMBL 43 | 220,950

Ligand Source

IUPHAR 129 | 129
Guide to Pharmacology 53 | 5,022
CHEMBL 49 | 221,632
SCIENTIFIC LITERATURE 4 | 269
DRUG LABEL 2 | 243
KEGG DRUG 2 | 45