Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 116
Tchem 79

Target Family

GPCR 70
Ion Channel 39
Enzyme 32
Transporter 23
Non-IDG 21
Nuclear Receptor 14
Kinase 3

Pharmalogical Action

AGONIST 42
ANTAGONIST 36
INHIBITOR 31
BLOCKER 13
ACTIVATOR 8
POSITIVE ALLOSTERIC MODULATOR 4
MODULATOR 3
NEGATIVE MODULATOR 3
PARTIAL AGONIST 2
ANTIBODY BINDING 1
INVERSE AGONIST 1

Ligand Source

IUPHAR 127
CHEMBL 73
SCIENTIFIC LITERATURE 8
DRUG LABEL 4
KEGG DRUG 2

Ligand Activity

IC50 56
Ki 43
EC50 11
Kd 11
Potency 4

Target

DRD2 21
DRD3 18
HTR2A 18
HTR2B 16
HTR6 15
KCNH2 14
SLC6A4 12
ADRA1D 11
ADRA2B 10
DRD4 10
HTR2C 10
SLC6A2 10
ADRA2A 9
ADRA2C 9
HRH1 9
SIGMAR1 9
DRD1 8
ADRB2 6
CACNA1C 6
CACNA1D 6
CHRM3 6
CYP2D6 6
CHRM1 5
CHRM2 5
CHRM4 5
CHRM5 5
HTR1A 5
HTR1D 5
HTR1F 5
SLC6A3 5
ADORA3 4
ADRB1 4
CACNA1F 4
DRD5 4
HTR1E 4
PTGS2 4
TDP1 4
ACHE 3
AR 3
CACNA1S 3
CATSPER1 3
CATSPER2 3
CATSPER3 3
CATSPER4 3
CHRFAM7A 3
GLRA2 3
HTR1B 3
HTR7 3
KCNN4 3
KCNT1 3
PPARD 3
PTGER1 3
RARB 3
SHBG 3
ABCB1 2
ACE 2
ADRA1A 2
ADRA1B 2
BCHE 2
CACNA1H 2
CMA1 2
CTSA 2
CTSK 2
CTSS 2
CYP2C9 2
ELANE 2
ESR1 2
ESR2 2
GABRA1 2
GABRA2 2
GABRA3 2
GLRA1 2
GLRA3 2
GPR17 2
KCNK2 2
KCNN2 2
KCNT2 2
MC3R 2
NQO2 2
NR3C1 2
P2RY12 2
PGR 2
PRSS1 2
PTGER2 2
PTGS1 2
RARA 2
RARG 2
RXRA 2
RXRB 2
RXRG 2
SERPINA6 2
SLCO1B3 2
TRPM4 2
CNR1 1
CYP2C19 1
GABRB2 1
HTR5A 1
NR3C2 1
PRKCD 1
RORB 1