Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 108
Tchem 74

Target Family

GPCR 70
Ion Channel 31
Enzyme 27
Transporter 24
Non-IDG 21
Nuclear Receptor 11
Kinase 3

Pharmalogical Action

AGONIST 44
ANTAGONIST 40
INHIBITOR 28
BLOCKER 12
ACTIVATOR 9
ALLOSTERIC MODULATOR 4
GATING INHIBITOR 4
MODULATOR 2
ANTIBODY BINDING 1
INVERSE AGONIST 1
POSITIVE ALLOSTERIC MODULATOR 1

Ligand Source

IUPHAR 119
CHEMBL 67
SCIENTIFIC LITERATURE 6
DRUG LABEL 4
KEGG DRUG 2

Ligand Activity

IC50 49
Ki 38
EC50 9
Kd 9
Potency 4

Target

DRD2 20
DRD3 17
HTR2A 17
HTR2B 15
ADRA1D 12
HTR6 12
SLC6A4 12
SLC6A2 11
ADRA2B 10
ADRA2C 10
DRD4 10
HTR2C 10
KCNH2 10
ADRA2A 9
DRD1 8
HRH1 8
SIGMAR1 8
ADRB2 6
CHRM3 6
HTR1F 6
CACNA1C 5
CHRM1 5
CHRM2 5
CHRM4 5
CHRM5 5
HTR1A 5
HTR1D 5
SLC6A3 5
ADRB1 4
CACNA1D 4
CACNA1F 4
CYP2D6 4
DRD5 4
HTR1E 4
HTR7 4
PTGS2 4
ACHE 3
ADORA3 3
AR 3
CATSPER1 3
CATSPER2 3
CATSPER3 3
CATSPER4 3
CHRFAM7A 3
GLRA2 3
HTR1B 3
KCNN4 3
PTGER1 3
SHBG 3
TDP1 3
ABCB1 2
ADRA1A 2
ADRA1B 2
BCHE 2
CMA1 2
CTSA 2
CTSK 2
CTSS 2
CYP2C9 2
ESR1 2
ESR2 2
GABRA1 2
GABRA2 2
GABRA3 2
GLRA3 2
HTR5A 2
KCNT2 2
MC3R 2
NQO2 2
P2RY12 2
PGR 2
PRSS1 2
PTGER2 2
PTGS1 2
SERPINA6 2
SLCO1B3 2
TRPM4 2
BDKRB1 1
CD3E 1
CD3G 1
CTSL 1
CYP2C19 1
ELANE 1
GABRB2 1
GLP1R 1
GRM8 1
HGFAC 1
HTR3B 1
KCNT1 1
KDR 1
KIT 1
MAOA 1
MAPT 1
NR3C2 1
PRKCG 1
PTH1R 1
RORB 1
SSTR3 1
TNNT2 1
TNNT3 1