Development Level

Tclin 2,874 | 130,166
Tchem 2,824 | 105,938

Target Family

GPCR 2,278 | 59,407
Enzyme 883 | 85,645
Kinase 837 | 33,996
Ion Channel 502 | 16,788
Nuclear Receptor 270 | 7,246
Transporter 203 | 9,204
Epigenetic 165 | 5,140
Non-IDG 155 | 16,175
TF/Epigenetic 10 | 108
Transcription Factor 8 | 410

Target

HTR2A 134 | 2,122
HTR1A 93 | 2,209
ADORA3 87 | 1,774
CHRM1 85 | 640
GRM5 85 | 661
HTR2B 84 | 551
CHRM2 82 | 688
FDFT1 81 | 232
ADORA1 80 | 1,178
ADORA2A 77 | 1,585
HMGCR 74 | 250
DRD2 71 | 2,432
GRM1 70 | 165
HRH1 69 | 553
HTR2C 69 | 1,221
ADORA2B 68 | 900
HTR6 68 | 2,009
KDR 67 | 1,715
HTR7 66 | 976
CHRM3 64 | 950
HTR1B 64 | 574
TRPA1 64 | 263
OPRM1 62 | 1,833
CHRM4 60 | 263
HTR1D 59 | 824
OPRK1 58 | 1,683
DRD4 56 | 1,320
PIK3CA 53 | 1,366
EGFR 52 | 1,445
PPARG 51 | 980
DRD3 50 | 2,406
OPRD1 49 | 1,607
PIK3CD 49 | 587
ADRA1D 48 | 728
HRH3 47 | 2,278
GRM2 45 | 129
PIK3CG 45 | 379
PTGER4 45 | 322
CHRM5 44 | 171
FLT3 44 | 535
ADRA1A 43 | 1,054
ADRB2 43 | 394
PIK3CB 41 | 450
SLC6A2 41 | 2,227
PTGER3 40 | 392
PDGFRB 39 | 322
SLC6A4 39 | 3,433
HTR1F 38 | 127
CDK2 37 | 420
TBXA2R 37 | 332
KIT 36 | 369
PTGS2 36 | 1,569
ADRA1B 35 | 583
GSK3B 35 | 523
JAK3 35 | 655
CDK1 34 | 206
ADRB1 33 | 291
HRH4 33 | 536
JAK2 33 | 1,350
NR3C1 33 | 1,509
PTAFR 33 | 225
CNR1 32 | 1,548
DRD1 32 | 450
GPR119 32 | 256
PTGER2 32 | 131
TRPV1 32 | 1,427
MTOR 31 | 1,755
BRD4 30 | 421
HTR1E 30 | 39
ADRA2B 28 | 185
AURKA 28 | 898
CCKAR 28 | 220
DRD5 28 | 116
FGFR1 28 | 351
HDAC1 28 | 2,280
JAK1 28 | 1,095
PPARA 28 | 377
PTGS1 28 | 342
ADRA2C 27 | 306
BTK 27 | 380
FLT1 27 | 178
GRM4 27 | 71
HDAC3 27 | 594
HDAC6 27 | 1,390
HTR3A 27 | 432
P2RY1 27 | 225
CCKBR 26 | 596
HTR4 26 | 369
MET 26 | 1,273
ADRA2A 25 | 389
AURKB 25 | 605
MAPK14 25 | 1,345
MTNR1B 25 | 643
PTGER1 25 | 412
PTGIR 25 | 88
S1PR1 25 | 810
BACE1 24 | 3,691
HTR5A 24 | 122
LCK 24 | 503
FDPS 23 | 168

Pharmalogical Action

INHIBITOR 141 | 542
ANTAGONIST 86 | 350
AGONIST 69 | 427
BLOCKER 32 | 129
POSITIVE ALLOSTERIC MODULATOR 10 | 51
ACTIVATOR 7 | 30
OPENER 5 | 16
PARTIAL AGONIST 5 | 14
GATING INHIBITOR 3 | 6
INVERSE AGONIST 3 | 9
NEGATIVE ALLOSTERIC MODULATOR 3 | 5
POSITIVE MODULATOR 3 | 15
MODULATOR 2 | 20
ALLOSTERIC ANTAGONIST 1 | 2
ALLOSTERIC MODULATOR 1 | 4

Ligand Activity

IC50 2,033 | 143,077
Ki 1,051 | 70,819
- 698 | 698
EC50 454 | 8,212
Kd 264 | 2,908
KB 17 | 17

Ligand Activity Source

Guide to Pharmacology 5,022 | 5,022
ChEMBL 39 | 220,950

Ligand Source

Guide to Pharmacology 5,022 | 5,022
CHEMBL 291 | 221,632
IUPHAR 53 | 129
SCIENTIFIC LITERATURE 51 | 269
DRUG LABEL 41 | 243
KEGG DRUG 4 | 45