Development Level

Tclin 1,685 | 130,166
Tchem 486 | 105,938

Target Family

GPCR 603 | 59,407
Enzyme 478 | 85,645
Ion Channel 352 | 16,788
Non-IDG 295 | 16,175
Transporter 225 | 9,204
Nuclear Receptor 207 | 7,246
Kinase 107 | 33,996
Epigenetic 13 | 5,140
Transcription Factor 8 | 410

Target

HRH1 83 | 553
DRD2 82 | 2,432
HTR2A 78 | 2,122
SLC6A2 72 | 2,227
NR3C1 69 | 1,509
KCNH2 65 | 4,432
SLC6A4 64 | 3,433
CHRM1 60 | 640
PTGS2 57 | 1,569
GABRA1 55 | 147
CHRM3 54 | 950
DRD3 53 | 2,406
PTGS1 52 | 342
ADRA1D 49 | 728
GABRG2 48 | 48
SLC6A3 48 | 1,766
OPRM1 46 | 1,833
ADRA1A 44 | 1,054
ADRB2 44 | 394
ADRA2C 43 | 306
ADRA2A 42 | 389
ADRA2B 42 | 185
ADRB1 42 | 291
CHRM2 42 | 688
CHRM4 42 | 263
SIGMAR1 40 | 1,854
HTR2C 39 | 1,221
SHBG 39 | 100
HTR2B 38 | 551
DRD4 37 | 1,320
GABRB2 37 | 37
CHRM5 35 | 171
GABRB3 35 | 53
HTR1A 35 | 2,209
AR 33 | 796
SCN5A 33 | 327
ESR1 32 | 967
HTR6 32 | 2,009
ADRA1B 31 | 583
GABRA2 30 | 139
GABRA3 30 | 68
GABRA5 29 | 481
HTR7 29 | 976
CACNA1C 28 | 111
HTR1B 28 | 574
HTR1D 28 | 824
PGR 27 | 640
CACNA1D 26 | 34
DRD1 25 | 450
SCN2A 25 | 118
ACHE 23 | 1,877
CA2 23 | 4,185
EGFR 23 | 1,445
ESR2 23 | 923
SCN1A 23 | 51
CA12 22 | 2,010
SCN3A 22 | 35
SCN4A 22 | 145
KDR 21 | 1,715
SCN10A 21 | 119
ACE 20 | 334
ADORA3 20 | 1,774
CA7 20 | 452
CYP2D6 19 | 45
HTR1E 19 | 39
OPRK1 19 | 1,683
CA1 18 | 2,654
GLRA1 18 | 45
HTR3A 18 | 432
KCNJ11 18 | 116
SCN9A 18 | 2,970
ABCC8 17 | 21
GABRG3 17 | 17
KIT 17 | 369
CHRNA1 16 | 23
GABRA4 16 | 21
HTR1F 16 | 127
NR3C2 16 | 175
CYP2C19 15 | 41
MAOA 15 | 467
OPRD1 15 | 1,607
PDGFRB 15 | 322
PPARG 15 | 980
RET 15 | 152
ABL1 14 | 631
DPP4 14 | 3,107
DRD5 14 | 116
GABRA6 14 | 25
GABRB1 14 | 14
MAOB 14 | 1,065
CA4 13 | 240
CA9 13 | 2,402
CHRNB1 13 | 13
CHRND 13 | 18
FLT4 13 | 105
GABRD 13 | 13
SCN8A 13 | 23
SERPINA6 13 | 21
SLC12A3 13 | 13
TUBB 13 | 14

Pharmalogical Action

INHIBITOR 542 | 542
AGONIST 427 | 427
ANTAGONIST 350 | 350
BLOCKER 129 | 129
ANTIBODY BINDING 57 | 57
POSITIVE ALLOSTERIC MODULATOR 51 | 51
ACTIVATOR 30 | 30
MODULATOR 20 | 20
OPENER 16 | 16
POSITIVE MODULATOR 15 | 15
PARTIAL AGONIST 14 | 14
INVERSE AGONIST 9 | 9
GATING INHIBITOR 6 | 6
NEGATIVE ALLOSTERIC MODULATOR 5 | 5
RELEASING AGENT 5 | 5
SUBSTRATE 5 | 5
ALLOSTERIC MODULATOR 4 | 4
PHARMACOLOGICAL CHAPERONE 3 | 3
ALLOSTERIC ANTAGONIST 2 | 2
OTHER 1 | 1

Ligand Activity

IC50 514 | 143,077
Ki 385 | 70,819
- 90 | 698
Kd 82 | 2,908
EC50 77 | 8,212
Potency 15 | 2,975
KB 1 | 17

Ligand Activity Source

ChEMBL 537 | 220,950
Guide to Pharmacology 382 | 5,022

Ligand Source

CHEMBL 1,219 | 221,632
Guide to Pharmacology 382 | 5,022
SCIENTIFIC LITERATURE 269 | 269
DRUG LABEL 243 | 243
IUPHAR 129 | 129
KEGG DRUG 45 | 45