Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 196
Tchem 31

Target Family

Non-IDG 90
GPCR 47
Enzyme 32
Kinase 29
Ion Channel 15
Transporter 10
Nuclear Receptor 8
Epigenetic 2
Transcription Factor 2

Pharmalogical Action

AGONIST 61
INHIBITOR 51
ANTIBODY BINDING 49
ANTAGONIST 30
ACTIVATOR 7
BLOCKER 3
PARTIAL AGONIST 3
POSITIVE MODULATOR 2
INVERSE AGONIST 1
OTHER 1
PHARMACOLOGICAL CHAPERONE 1
POSITIVE ALLOSTERIC MODULATOR 1

Ligand Source

DRUG LABEL 196
CHEMBL 31
SCIENTIFIC LITERATURE 6
IUPHAR 4
KEGG DRUG 1

Ligand Activity

IC50 35
Ki 23
EC50 11
Kd 4
Potency 1

Target

HTR2A 13
DRD2 10
HTR1A 8
EPOR 7
INSR 7
KCNH2 6
HRH1 5
HTR2B 5
HTR2C 5
IFNAR1 5
IFNAR2 5
MS4A1 5
SLC6A4 5
TNF 5
ADRA2A 4
DRD3 4
DRD4 4
EGFR 4
IL2RA 4
KDR 4
NR3C1 4
PDGFRA 4
RET 4
VEGFA 4
ADRA2B 3
ADRB2 3
CSF3R 3
CYP2D6 3
CYP3A4 3
DRD1 3
ERBB2 3
HTR3A 3
HTR6 3
IL2RB 3
IL2RG 3
ITGA2B 3
ITGB3 3
JAK1 3
KIT 3
OPRM1 3
PARP1 3
PARP2 3
PLG 3
ADRA1D 2
ADRA2C 2
AVPR1A 2
CD274 2
CD80 2
CD86 2
CDK4 2
CDK6 2
CFTR 2
CHRM1 2
CHRM2 2
CHRM3 2
CHRM4 2
CHRM5 2
CYP11B1 2
CYP11B2 2
CYP2C19 2
ESR2 2
F2 2
FLT3 2
FLT4 2
GABRA1 2
GABRA3 2
GABRB2 2
GABRB3 2
GHR 2
GLP1R 2
HDAC1 2
HDAC10 2
HDAC11 2
HDAC2 2
HDAC3 2
HDAC4 2
HDAC5 2
HDAC6 2
HDAC7 2
HDAC8 2
HTR1D 2
HTR7 2
IL1B 2
IL5 2
ITGA4 2
ITGAL 2
OXTR 2
PDGFRB 2
PGR 2
PTGIR 2
SIGMAR1 2
SLC18A2 2
TNKS 2
TUBB 2
TUBB1 2
TUBB2A 2
TUBB2B 2
TUBB4B 2
TUBB8 2
TYK2 2