Development Level

Tclin 243 | 130,166
Tchem 45 | 105,938

Target Family

Non-IDG 97 | 16,175
GPCR 56 | 59,407
Kinase 47 | 33,996
Enzyme 38 | 85,645
Ion Channel 18 | 16,788
Transporter 11 | 9,204
Nuclear Receptor 9 | 7,246
Epigenetic 4 | 5,140
Transcription Factor 1 | 410

Target

HTR2A 15 | 2,122
DRD2 13 | 2,432
HTR1A 10 | 2,209
KDR 8 | 1,715
EGFR 7 | 1,445
EPOR 7 | 7
INSR 7 | 78
RET 7 | 152
ERBB2 6 | 375
FLT4 6 | 105
HTR2C 6 | 1,221
PDGFRA 6 | 136
CDK6 5 | 202
DRD4 5 | 1,320
FLT3 5 | 535
HRH1 5 | 553
HTR2B 5 | 551
HTR6 5 | 2,009
IFNAR1 5 | 5
IFNAR2 5 | 5
KCNH2 5 | 4,432
MS4A1 5 | 5
PARP1 5 | 1,628
TNF 5 | 308
ADRA2A 4 | 389
CDK4 4 | 505
CFTR 4 | 179
DRD3 4 | 2,406
FLT1 4 | 178
HDAC1 4 | 2,280
HDAC2 4 | 645
HDAC4 4 | 375
HDAC6 4 | 1,390
HDAC9 4 | 104
IL2RA 4 | 4
JAK1 4 | 1,095
JAK3 4 | 655
KIT 4 | 369
MAP3K19 4 | 19
MINK1 4 | 15
NR3C1 4 | 1,509
OPRM1 4 | 1,833
PARP2 4 | 71
TNKS 4 | 193
VEGFA 4 | 35
ADRA2B 3 | 185
ADRA2C 3 | 306
ADRB2 3 | 394
ALK 3 | 539
AVPR1A 3 | 409
CD274 3 | 9
CHRM1 3 | 640
CHRM2 3 | 688
CHRM3 3 | 950
CHRM4 3 | 263
CHRM5 3 | 171
CSF3R 3 | 4
CYP11B2 3 | 711
CYP3A4 3 | 58
DRD1 3 | 450
ERBB4 3 | 46
GLP1R 3 | 123
HDAC10 3 | 186
HDAC11 3 | 122
HDAC3 3 | 594
HDAC5 3 | 95
HDAC7 3 | 87
HDAC8 3 | 622
HTR1B 3 | 574
HTR1D 3 | 824
HTR7 3 | 976
IL2RB 3 | 3
IL2RG 3 | 3
IL6ST 3 | 3
ITGA2B 3 | 6
ITGB3 3 | 3
JAK2 3 | 1,350
MET 3 | 1,273
PDGFRB 3 | 322
PLG 3 | 280
SLC6A4 3 | 3,433
STK10 3 | 15
TYK2 3 | 132
ADRB1 2 | 291
CHEK2 2 | 53
CSNK1D 2 | 21
CYP2C19 2 | 41
CYP2D6 2 | 45
ESR2 2 | 923
F2 2 | 2,721
GABRA3 2 | 68
GABRB2 2 | 37
GAK 2 | 23
GHR 2 | 3
IL23A 2 | 2
ITK 2 | 238
MAP4K1 2 | 6
PAK3 2 | 9
TNKS2 2 | 199
ULK1 2 | 6

Pharmalogical Action

INHIBITOR 81 | 542
AGONIST 67 | 427
ANTIBODY BINDING 52 | 57
ANTAGONIST 33 | 350
ACTIVATOR 7 | 30
BLOCKER 4 | 129
PARTIAL AGONIST 4 | 14
PHARMACOLOGICAL CHAPERONE 3 | 3
INVERSE AGONIST 1 | 9
OTHER 1 | 1
POSITIVE ALLOSTERIC MODULATOR 1 | 51
POSITIVE MODULATOR 1 | 15

Ligand Activity

IC50 53 | 143,077
Ki 35 | 70,819
EC50 12 | 8,212
- 6 | 698
Kd 6 | 2,908
Potency 1 | 2,975

Ligand Activity Source

ChEMBL 49 | 220,950
Guide to Pharmacology 41 | 5,022

Ligand Source

DRUG LABEL 243 | 243
Guide to Pharmacology 41 | 5,022
CHEMBL 29 | 221,632
SCIENTIFIC LITERATURE 9 | 269
IUPHAR 2 | 129