Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 214
Tchem 39

Target Family

Non-IDG 98
GPCR 52
Kinase 38
Enzyme 29
Ion Channel 16
Transporter 11
Nuclear Receptor 9
Epigenetic 2
Transcription Factor 2

Pharmalogical Action

AGONIST 68
INHIBITOR 59
ANTIBODY BINDING 52
ANTAGONIST 30
ACTIVATOR 6
BLOCKER 3
PARTIAL AGONIST 3
PHARMACOLOGICAL CHAPERONE 3
INVERSE AGONIST 1
OTHER 1
POSITIVE ALLOSTERIC MODULATOR 1
POSITIVE MODULATOR 1

Ligand Source

DRUG LABEL 214
CHEMBL 34
SCIENTIFIC LITERATURE 10
IUPHAR 4

Ligand Activity

IC50 39
Ki 23
EC50 11
Kd 6
Potency 1

Target

HTR2A 13
DRD2 10
HTR1A 8
EPOR 7
INSR 7
KCNH2 6
TNF 6
DRD4 5
EGFR 5
HRH1 5
HTR2B 5
HTR2C 5
IFNAR1 5
IFNAR2 5
KDR 5
MS4A1 5
PDGFRA 5
SLC6A4 5
ADRA2A 4
DRD3 4
ERBB2 4
FLT3 4
HTR6 4
IL2RA 4
NR3C1 4
RET 4
VEGFA 4
ADRA2B 3
ADRB2 3
CD274 3
CDK4 3
CDK6 3
CFTR 3
CSF3R 3
CYP2D6 3
CYP3A4 3
DRD1 3
FLT1 3
FLT4 3
GLP1R 3
HTR3A 3
IL2RB 3
IL2RG 3
IL6ST 3
ITGA2B 3
ITGB3 3
JAK1 3
KIT 3
MAP3K19 3
OPRM1 3
PARP1 3
PARP2 3
ALK 2
AVPR1A 2
CD80 2
CD86 2
CHRM1 2
CHRM2 2
CHRM3 2
CHRM4 2
CHRM5 2
CYP11B1 2
CYP11B2 2
CYP2C19 2
ESR2 2
F2 2
GABRA1 2
GABRA3 2
GABRB2 2
GHR 2
HDAC10 2
HDAC11 2
HDAC2 2
HDAC3 2
HDAC4 2
HDAC5 2
HDAC6 2
HTR7 2
IGF1R 2
IL1B 2
IL23A 2
IL5 2
IL6R 2
ITGA4 2
ITGAL 2
MINK1 2
PDGFRB 2
PGR 2
PLG 2
PTGIR 2
PTH1R 2
SLC18A2 2
TNKS 2
TNKS2 2
TUBB 2
TUBB1 2
TUBB2A 2
TUBB2B 2
TUBB4B 2
TUBB8 2