Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Development Level

Tclin 123,344
Tchem 95,515

Target Family

Enzyme 74,825
GPCR 57,175
Kinase 33,172
Ion Channel 16,376
Non-IDG 13,820
Transporter 9,042
Nuclear Receptor 6,968
Epigenetic 4,987
Transcription Factor 414
TF/Epigenetic 101
oGPCR 1

Pharmalogical Action

INHIBITOR 432
AGONIST 395
ANTAGONIST 313
BLOCKER 114
ANTIBODY BINDING 57
POSITIVE ALLOSTERIC MODULATOR 41
ACTIVATOR 27
MODULATOR 19
OPENER 15
POSITIVE MODULATOR 14
PARTIAL AGONIST 12
INVERSE AGONIST 8
GATING INHIBITOR 6
RELEASING AGENT 5
SUBSTRATE 5
NEGATIVE ALLOSTERIC MODULATOR 4
ALLOSTERIC MODULATOR 3
PHARMACOLOGICAL CHAPERONE 3
ALLOSTERIC ANTAGONIST 1
OTHER 1

Ligand Source

CHEMBL 210,482
SCIENTIFIC LITERATURE 231
DRUG LABEL 210
IUPHAR 113
KEGG DRUG 41

Ligand Activity

IC50 134,292
Ki 65,575
EC50 7,734
Potency 2,972
Kd 2,603
AC50 517

Target

KCNH2 4,416
CA2 4,179
BACE1 3,667
SLC6A4 3,404
DPP4 3,094
SCN9A 2,961
F2 2,715
PDE10A 2,698
CA1 2,641
HSD11B1 2,490
CA9 2,401
DRD2 2,367
DRD3 2,358
REN 2,302
MAPT 2,286
HDAC1 2,252
HRH3 2,231
SLC6A2 2,194
HTR1A 2,121
MCHR1 2,026
HTR2A 1,998
CA12 1,996
HTR6 1,944
ACACB 1,928
CNR2 1,908
ACHE 1,867
ALOX5AP 1,860
SIGMAR1 1,848
TACR1 1,832
OPRM1 1,772
SLC6A3 1,746
MTOR 1,724
ADORA3 1,687
KDR 1,651
OPRK1 1,626
PARP1 1,622
CTSS 1,561
OPRD1 1,561
PTGS2 1,544
CNR1 1,517
ADORA2A 1,511
NR3C1 1,478
MDM2 1,448
P2RX7 1,398
TRPV1 1,397
CTSK 1,395
EGFR 1,393
EPHX2 1,366
HDAC6 1,363
MAPK14 1,320
JAK2 1,317
PIK3CA 1,313
PTGDR2 1,309
DRD4 1,272
MET 1,247
CCR5 1,186
ADAM17 1,185
CRHR1 1,161
HTR2C 1,154
CYP19A1 1,134
PIM1 1,122
PDE5A 1,107
ADORA1 1,099
JAK1 1,067
MAOB 1,057
MC4R 1,050
ADRA1A 1,014
BRAF 1,004
ELANE 973
ESR1 944
OPRL1 944
SLC5A2 944
BCL2 930
PPARG 927
HTR7 911
ESR2 901
FAAH 900
CHRM3 894
AURKA 870
SYK 848
CHEK1 847
HCRTR2 837
ADORA2B 834
CCR2 829
P2RX3 822
BCHE 813
PDE4B 804
PRSS1 789
S1PR1 786
TDP1 782
AR 776
CTSL 776
HTR1D 770
MAPK1 761
ALOX5 751
GNRHR 750
AKT1 725
CASP3 722
CYP11B2 707
EDNRA 703