trandolapril
Ligand Summary
The effect of trandolapril in hypertension appears to result primarily from the inhibition of circulating and tissue ACE activity thereby reducing angiotensin II formation, decreasing vasoconstriction, decreasing aldosterone secretion, and increasing plasma renin. Decreased aldosterone secretion leads to diuresis, natriuresis, and a small increase of serum potassium. Trandolapril is deesterified to the diacid metabolite, trandolaprilat, which is approximately eight times more active as an inhibitor of ACE activity.
UNII: 1T0N3G9CRC
PubChem: 5484727
Guide to Pharmacology: 6453
ChEMBL: CHEMBL1519
DrugCentral: 2712
LyCHI: FBX1D71CTJT9
Target Activities
3 Activities
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