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sirolimus

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. Limited data describing efficacy in patients with COVID-19 is available. However, its efficacy and safety in the treatment of COVID-19 was not established.
Synonyms & Links
Guide to Pharmacology: 6031
DrugCentral: 2446
LyCHI:  KG4MHLNXP966


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Target Activities