pralatrexate
Ligand Summary
Pralatrexate is a folate analog metabolic inhibitor that competitively inhibits dihydrofolate reductase. It is also a competitive inhibitor for polyglutamylation by the enzyme folylpolyglutamyl synthetase. This inhibition results in the depletion of thymidine and other biological molecules the synthesis of which depends on single carbon transfer.
UNII: A8Q8I19Q20
PubChem: 148121
Guide to Pharmacology: 6840
ChEMBL: CHEMBL1201746
DrugCentral: 4117
LyCHI: SPPQGS51D4V2
Target Activities
7 Activities
Items per page:
1 – 7 of 7
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