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leflunomide

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
Synonyms & Links
UNII: G162GK9U4W
PubChem: 3899
Guide to Pharmacology: 6825
ChEMBL: CHEMBL960
DrugCentral: 1552
LyCHI:  9VYUZN1KLN3X


Target Activities