irinotecan
Ligand Summary
Irinotecan is a derivative of camptothecin. Camptothecins act as specific inhibitors of the enzyme DNA topoisomerase I. Irinotecan and its active metabolite SN-38 bind reversibly to the topoisomerase I-DNA complex and induce single-strand DNA lesions which block the DNA replication fork and are responsible for the cytotoxicity. Irinotecan is metabolized by carboxylesterase to SN-38. SN-38 is approximately 1000 times as potent as irinotecan as an inhibitor of topoisomerase I purified from human and rodent tumour cell lines.
UNII: 7673326042
PubChem: 74990
PubChem: 60838
PubChem: 23581792
ChEMBL: CHEMBL541887
ChEMBL: CHEMBL481
ChEMBL: CHEMBL1200512
DrugCentral: 1482
LyCHI: PZX523N3G85U
Target Activities
3 Activities
Items per page:
1 – 3 of 3
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