glycopyrronium bromide
Ligand Summary
Glycopyrrolate is a long-acting muscarinic antagonist, which is often referred to as an anticholinergic. It has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of M3 receptor at the smooth muscle leading to bronchodilation. The competitive and reversible nature of antagonism was shown with human and animal origin receptors and isolated organ preparations. In preclinical in vitro as well as in vivo studies, prevention of methacholine and acetylcholine induced bronchoconstrictive effects was dose-dependent and lasted longer than 24 hours. The clinical relevance of these findings is unknown. The bronchodilation following inhalation of glycopyrrolate is predominantly a site-specific effect.
UNII: A14FB57V1D
PubChem: 11693
PubChem: 3494
Guide to Pharmacology: 7459
ChEMBL: CHEMBL1201027
ChEMBL: CHEMBL1201335
DrugCentral: 4302
LyCHI: G7AWN7FW4YGK
Target Activities
20 Activities
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