famotidine
Ligand Summary
A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. Computer-aided, structure-based, virtual screening of libraries of compounds against SARS-CoV-2 proteins suggested potential for famotidine to interact with viral proteases in-volved in coronavirus replication. HOWEVER, there is no clinical trial evidence supporting efficacy or safety for treatment of COVID-19.
UNII: 5QZO15J2Z8
PubChem: 5353622
ChEMBL: CHEMBL902
DrugCentral: 1129
LyCHI: A7XJAV9JH92C
Target Activities
14 Activities
Items per page:
1 – 10 of 14
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | ||||||
Ki | ||||||
Ki | ||||||
Ki | ||||||
IC50 | ||||||
Ki | ||||||
Ki | ||||||
Ki | ||||||
Ki | ||||||
Ki | ||||||