enzalutamide
Ligand Summary
Enzalutamide is an androgen receptor inhibitor that acts on different steps in the androgen receptor signaling pathway. Enzalutamide has been shown to competitively inhibit androgen binding to androgen receptors and inhibit androgen receptor nuclear translocation and interaction with DNA. A major metabolite, N‑desmethyl enzalutamide, exhibited similar in vitro activity to enzalutamide. Enzalutamide decreased proliferation and induced cell death of prostate cancer cells in vitro, and decreased tumor volume in a mouse prostate cancer xenograft model.
UNII: 93T0T9GKNU
PubChem: 15951529
Guide to Pharmacology: 6812
ChEMBL: CHEMBL1082407
DrugCentral: 4628
LyCHI: A7M3QY3P22VZ
Target Activities
14 Activities
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