elobixibat
Ligand Summary
Elobixibat is an IBAT inhibitor approved in Japan for the treatment of chronic constipation. IBAT is the bile acid/sodium symporter responsible for the reuptake of bile acids in the ileum which is the initial step in the enterohepatic circulation. By inhibiting the uptake of bile acids, elobixibat increases the bile acid concentration in the gut, and this accelerates intestinal passage and softens the stool.
UNII: 865UEK4EJC
PubChem: 9939892
Guide to Pharmacology: 9996
ChEMBL: CHEMBL3039515
DrugCentral: 5277
LyCHI: 629QL4UG8DYJ
Target Activities
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | ||||||
IC50 | INHIBITOR | |||||