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eliglustat

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Eliglustat tartrate is a small molecule inhibitor of glucosylceramide synthase that resembles the ceramide substrate for the enzyme. Gaucher disease is caused by a deficiency of the lysosomal enzyme acid beta-glucosidase. Acid beta-glucosidase catalyzes the conversion of the sphingolipid glucocerebroside into glucose and ceramide. The enzymatic deficiency causes an accumulation of glucosylceramide (GL-1) primarily in the lysosomal compartment of macrophages, giving rise to foam cells or Gaucher cells"."
Synonyms & Links
DrugCentral: 4834
LyCHI:  LJXP8S6ZRYF3


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Target Activities