eliglustat
Ligand Summary
Eliglustat tartrate is a small molecule inhibitor of glucosylceramide synthase that resembles the ceramide substrate for the enzyme. Gaucher disease is caused by a deficiency of the lysosomal enzyme acid beta-glucosidase. Acid beta-glucosidase catalyzes the conversion of the sphingolipid glucocerebroside into glucose and ceramide. The enzymatic deficiency causes an accumulation of glucosylceramide (GL-1) primarily in the lysosomal compartment of macrophages, giving rise to foam cells or Gaucher cells"."
UNII: DR40J4WA67
PubChem: 23652731
ChEMBL: CHEMBL2110588
DrugCentral: 4834
LyCHI: LJXP8S6ZRYF3
Target Activities
2 Activities
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IC50 | INHIBITOR | |||||