dofetilide
Ligand Summary
Dofetilide show Vaughan Williams Class III antiarrhythmic activity. The mechanism of action is blockade of the cardiac ion channel carrying the rapid component of the delayed rectifier potassium current, IKr. At concentrations covering several orders of magnitude, dofetilide blocks only IKr with no relevant block of the other repolarizing potassium currents (e.g., IKs, IK1). At clinically relevant concentrations, dofetilide has no effect on sodium channels (associated with Class I effect), adrenergic alpha-receptors, or adrenergic beta-receptors.
UNII: R4Z9X1N2ND
PubChem: 71329
Guide to Pharmacology: 2604
ChEMBL: CHEMBL473
DrugCentral: 942
LyCHI: 1T1U6CGXR87B
Target Activities
23 Activities
Items per page:
1 – 10 of 23
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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IC50 | ||||||
IC50 | ||||||
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