You are using an outdated browser. Please upgrade your browser to improve your experience.

clozapine

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Synonyms & Links
PubChem: 2818
Guide to Pharmacology: 38
DrugCentral: 722
LyCHI:  RKTD5RVPC8UN


loading...
Target Activities