cilastatin
Ligand Summary
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
UNII: 141A6AMN38
PubChem: 6435415
ChEMBL: CHEMBL766
DrugCentral: 640
LyCHI: H658LNLWPZF7
Target Activities
1 Activities
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