You are using an outdated browser. Please upgrade your browser to improve your experience.

cerivastatin

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Cerivastatin is a competitive inhibitor of HMG-CoA reductase, which is responsible for the conversion of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) to mevalonate, a precursor of sterols, including cholesterol. The inhibition of cholesterol biosynthesis by cerivastatin reduces the level of cholesterol in hepatic cells, which stimulates the synthesis of LDL receptors, thereby increasing the uptake of cellular LDL particles. The end result of these biochemical processes is a reduction of the plasma cholesterol concentration.
Synonyms & Links
Guide to Pharmacology: 2950
DrugCentral: 577
LyCHI:  D9FUQWJDU71Y


loading...
Target Activities