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  3. axitinib

axitinib

oral Angiogenesis Inhibitor that inhibits the tyrosine kinase activities of both VEGFR and PDGFRbeta

Structure of axitinib

Synonym

axitinib
CHEMBL1289926
DrugCentral4225
CID6450551
AG-013736

Target Relevance

Vascular endothelial growth factor receptor 1 Tclin
INHIBITOR 542
pKd 2908 8.24
pKd 2908 8.24
Aurora kinase C Tchem
pKd 2908 8.89
pKd 2908 8.89
Tyrosine-protein kinase ABL1 Tclin
pKd 2908 7.64
Serine/threonine-protein kinase PLK4 Tchem
pKi 70819 8.38
pKd 2908 7.8
Platelet-derived growth factor receptor beta Tclin
pKd 2908 9.24
Mast/stem cell growth factor receptor Kit Tclin
pKd 2908 8.46
Vascular endothelial growth factor receptor 2 Tclin
pKd 2908 8.23
Aurora kinase B Tchem
pKd 2908 7.96
Macrophage colony-stimulating factor 1 receptor Tclin
pKd 2908 7.68
Platelet-derived growth factor receptor alpha Tclin
pKd 2908 9.29

Molecular Definition

Canonical SMILES CNC(=O)C1=C(SC2=CC=C3C(NN=C3\C=C\C3=CC=CC=N3)=C2)C=CC=C1
Formula C22H18N4OS
Molecular Weight 386.47 da
Stereocenters 0/0
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Build: Sat Nov 17 23:53:08 EST 2018 (commit: a759bb7)

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