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aprepitant

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CINV). Aprepitant has been shown in animal models to inhibit emesis induced by cytotoxic chemotherapeutic agents, such as cisplatin, via central actions.
Synonyms & Links
Guide to Pharmacology: 3490
DrugCentral: 230
LyCHI:  LHAQUS517C7W


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Target Activities