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inqovi

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Cedazuridine inhibits cytidine deaminase (CDA), an enzyme that catalyzes the degradation of cytidine, including the cytidine analog decitabine (a nucleoside metabolic inhibitor). Because high levels of CDA in the gastrointestinal tract and liver degrade decitabine and limit its oral bioavailability, administration of cedazuridine with decitabine increases systemic exposure of decitabine. Inqovi is a combination of decitabine and cedazuridine for treatment of adult patients with myelodysplastic syndromes (MDS).
Synonyms & Links
DrugCentral: 5402
LyCHI:  UR6HXAT2SP5G


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Target Activities