Currently the ligands view is a work in progress and should not be considered a definitive resource yet

Library

Selleck Bioactive Compound 855
NCATS MIPE 567
Selleck FDA Approved Drug 410
Selleck Kinase Inhibitor 230
Selleck Target Selective Inhibitor 213

Development Level

Tclin 127,306
Tchem 103,180

Target Family

Enzyme 84,773
GPCR 57,167
Kinase 33,162
Ion Channel 16,308
Non-IDG 16,032
Transporter 9,020
Nuclear Receptor 6,975
Epigenetic 4,976
Transcription Factor 404
TF/Epigenetic 98

Target

KCNH2 4,416
CA2 4,179
F10 3,874
BACE1 3,667
SLC6A4 3,404
DPP4 3,095
SCN9A 2,961
F2 2,715
PDE10A 2,698
CA1 2,641
HSD11B1 2,490
CA9 2,401
DRD2 2,367
DRD3 2,358
REN 2,302
MAPT 2,286
HDAC1 2,252
MMP2 2,243
HRH3 2,231
SLC6A2 2,194
HTR1A 2,121
MMP13 2,029
MCHR1 2,026
HTR2A 1,998
CA12 1,996
HTR6 1,944
ACACB 1,928
CNR2 1,908
ACHE 1,867
ALOX5AP 1,860
SIGMAR1 1,848
TACR1 1,832
MMP9 1,826
OPRM1 1,772
SLC6A3 1,746
MTOR 1,724
ADORA3 1,687
KDR 1,651
OPRK1 1,626
PARP1 1,622
CTSS 1,561
OPRD1 1,561
PTGS2 1,543
CNR1 1,517
ADORA2A 1,511
NR3C1 1,478
MDM2 1,448
MMP1 1,448
P2RX7 1,398
TRPV1 1,397
CTSK 1,395
EGFR 1,393
EPHX2 1,366
HDAC6 1,363
MMP3 1,342
MAPK14 1,320
JAK2 1,317
PIK3CA 1,313
PTGDR2 1,309
DRD4 1,272
MET 1,247
CCR5 1,186
ADAM17 1,185
CRHR1 1,161
HTR2C 1,154
CYP19A1 1,134
PIM1 1,122
PDE5A 1,108
ADORA1 1,099
JAK1 1,067
MAOB 1,057
MC4R 1,050
ADRA1A 1,014
BRAF 1,004
ELANE 973
SLC5A2 946
ESR1 944
OPRL1 944
BCL2 930
PPARG 929
HTR7 911
ESR2 901
FAAH 900
CHRM3 894
MMP8 874
AURKA 870
SYK 848
CHEK1 847
HCRTR2 837
ADORA2B 834
CCR2 829
P2RX3 822
BCHE 813
PDE4B 804
PRSS1 789
S1PR1 786
TDP1 782
AR 776
CTSL 776
HTR1D 770

Pharmalogical Action

INHIBITOR 471
AGONIST 405
ANTAGONIST 314
BLOCKER 117
ANTIBODY BINDING 57
POSITIVE ALLOSTERIC MODULATOR 41
ACTIVATOR 28
MODULATOR 19
OPENER 15
POSITIVE MODULATOR 14
PARTIAL AGONIST 12
INVERSE AGONIST 8
GATING INHIBITOR 6
RELEASING AGENT 5
SUBSTRATE 5
NEGATIVE ALLOSTERIC MODULATOR 4
ALLOSTERIC MODULATOR 4
PHARMACOLOGICAL CHAPERONE 3
ALLOSTERIC ANTAGONIST 1
OTHER 1

Ligand Activity

IC50 141,067
Ki 69,787
EC50 7,763
Potency 2,975
Kd 2,644
AC50 517

Ligand Source

CHEMBL 221,399
SCIENTIFIC LITERATURE 251
DRUG LABEL 219
IUPHAR 121
KEGG DRUG 44