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vesicoureteral reflux 3

Disease Summary
Associated Targets (1)
Tbio

1


Mondo Description Any vesicoureteral reflux in which the cause of the disease is a mutation in the SOX17 gene.
Uniprot Description A disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.
Mondo Term and Equivalent IDs
MONDO:0013356:  vesicoureteral reflux 3
UMLS:C3150927: