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spastic ataxia 2

Disease Summary
Associated Targets (1)
Tbio

1


Mondo Description Autosomal recessive spastic paraplegia type 58 is a rare, complex subtype of hereditary spastic paraplegia characterized by variable onset of slowly progressive lower limb spasticity and weakness and prominent cerebellar ataxia, associated with gait disturbances, dysarthria, increased deep tendon reflexes and extensor plantar responses. Additional features may include involuntary movements (i.e. clonus, tremor, fasciculations, chorea), decreased vibration sense, oculomotor abnormalities (e.g. nystagmus) and distal amyotrophy in the upper and lower limbs.
Uniprot Description A neurologic disorder characterized by cerebellar ataxia, dysarthria, and variable spasticity of the lower limbs. Cognition is not affected.
Mondo Term and Equivalent IDs
MONDO:0012651:  spastic ataxia 2
MESH:C566969: 
Orphanet:397946: 
UMLS:C1969796: