You are using an outdated browser. Please upgrade your browser to improve your experience.

Cushing disease due to pituitary adenoma

Disease Summary
Associated Targets (11)
Tbio

7

Tchem

3

Tclin

1


GARD Rare
Mondo Description Cushing's syndrome due to abnormally high secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland.
Uniprot Description A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA4 results in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.
Disease Ontology Description A functioning pituitary adenoma that characterized by excess cortisol a primary cause of Cushing's syndrome.
Mondo Term and Equivalent IDs
MONDO:0009050:  Cushing disease due to pituitary adenoma
GARD:0012867: 
MESH:D049913: 
NCIT:C113210: 
Orphanet:96253: 
SCTID:254958004: 
UMLS:C0221406: 
UMLS:C1306214: