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diabetic ketoacidosis

Disease Summary
Associated Targets (3)
Tbio

2

Tchem

1


Mondo Description The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.
Uniprot Description An atypical form of diabetes mellitus characterized by an acute initial presentation with severe hyperglycemia and ketosis, as seen in classic type 1 diabetes, but after initiation of insulin therapy, prolonged remission is often possible with cessation of insulin therapy and maintenance of appropriate metabolic control. Metabolic studies show a markedly blunted insulin secretory response to glucose, partially reversible with the improvement of blood glucose control. Variable levels of insulin resistance are observed, especially in obese patients. Pancreatic beta-cell autoimmunity is a rare finding.
Mondo Term and Equivalent IDs
MONDO:0012819:  diabetic ketoacidosis
COHD:443727: 
EFO:1000897: 
ICD9:250.10: 
MESH:D016883: 
SCTID:420422005: 
UMLS:C0011880: