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glioblastoma

Disease Summary
Associated Targets (6040)
Tbio

4278

Tchem

757

Tdark

726

Tclin

279


GARD Rare
Mondo Description The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)
Disease Ontology Description An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.
Mondo Term and Equivalent IDs
MONDO:0018177:  glioblastoma
GARD:0002491: 
NCIT:C3058: 
ONCOTREE:GB: 
ONCOTREE:GBM: 
Orphanet:360: 
SCTID:393563007: 
UMLS:C0017636: 
UMLS:C1621958: 
UMLS:CN227279: