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tetanus

Disease Summary
Associated Targets (12)
Tclin

9

Tbio

2

Tchem

1


GARD Rare
Mondo Description A serious infectious disorder that follows wound contamination by the Gram-positive bacterium Clostridium tetani. The bacteria produce a neurotoxin called tetanospasmin, which causes muscle spasm in the jaw and other anatomic sites.
Disease Ontology Description A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has material basis in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.
Mondo Term and Equivalent IDs
MONDO:0005526:  tetanus
COHD:435740: 
DOID:11338: tetanus
EFO:0005593: 
GARD:0005144: 
MESH:D013742: 
NCIT:C85185: 
Orphanet:3299: 
SCTID:276202003: 
SCTID:76902006: 
UMLS:C0039614: