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rheumatic heart disease

Disease Summary
Associated Targets (5)
Tchem

4

Tclin

1


Mondo Description An autoinflammatory condition following an infection with Group A Beta Hemolytic Streptococcus (GABHS), in which the heart is attacked by antibodies formed in reaction to a recent GABHS infection. Chief anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords, all of which can result in valvular dysfunction.
Disease Ontology Description A heart valve disease that is characterized by repeated inflammation with fibrinous repair. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.It is caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage.
Mondo Term and Equivalent IDs
MONDO:0006955:  rheumatic heart disease
COHD:319825: 
EFO:1001161: 
ICD10:I05.I09: 
ICD9:398.90: 
MESH:D012214: 
NCIT:C34882: 
SCTID:23685000: