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progressive multifocal leukoencephalopathy
Disease Summary
Associated Targets ()
Mondo Description Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but itrarelycauses symptoms unless the immune system becomes severely weakened.The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as Hodgkins disease, lymphoma, and sarcoidosis. PML is most common among individuals with acquired immune deficiency syndrome (AIDS).
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Counts of Target Development Levels for diseases known to be associated with this disease. If the disease has a valid DOID, targets known to be associated with all child diseases are aggregated. Click "Explore Associated Targets" to view more facets and details for the target list.
Description from Mondo Disease Ontology.
DataSources which have contributed target associations to this disease, and the identifiers by which the disease is referenced.
COHD:433957
DOID:643
EFO:0007455
GARD:0007468
ICD10:A81.2
ICD9:046.3
MESH:D007968
NCIT:C26815
Orphanet:217260
SCTID:22255007
UMLS:C0023524
MONDO:0016318
High level summary of knowledge for a disease, including descriptions and datasource references.