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Paget disease of bone 2, early-onset
Disease Summary
Associated Targets (2)
Tbio
2
Uniprot Description A form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone.
Mondo Term and Equivalent IDs
MONDO:0011183: Paget disease of bone 2, early-onset
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Counts of Target Development Levels for diseases known to be associated with this disease. If the disease has a valid DOID, targets known to be associated with all child diseases are aggregated. Click "Explore Associated Targets" to view more facets and details for the target list.
Description from UniProt.
DataSources which have contributed target associations to this disease, and the identifiers by which the disease is referenced.
OMIM:602080
UMLS:C4085251
MONDO:0011183
High level summary of knowledge for a disease, including descriptions and datasource references.