You are using an outdated browser. Please upgrade your browser to improve your experience.

Alzheimer disease type 1

Disease Summary
Associated Targets (9)
Tchem

4

Tbio

3

Tclin

2


GARD Rare
Uniprot Description A familial early-onset form of Alzheimer disease. It can be associated with cerebral amyloid angiopathy. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death.
Mondo Term and Equivalent IDs
MONDO:0007088:  Alzheimer disease type 1
GARD:0009465: 
UMLS:C2931257: