Name Development Level Target Family
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Tclin Kinase
Name Description
idelalisib Idelalisib is an inhibitor of PI3K-delta kinase, which is expressed in normal and malignant B-cells. Idelalisib induced apoptosis and inhibited proliferation in cell lines derived from malignant B-cells and in primary tumor cells. Idelalisib inhibits several cell signaling pathways, including B-cell receptor (BCR) signaling and the CXCR4 and CXCR5 signaling, which are involved in trafficking and homing of B-cells to the lymph nodes and bone marrow.
TCRDv4.6.0
DrugCentral Indication
DrugCentral
idelalisib