Name Development Level Target Family
Acid-sensing ion channel 3 Tchem Ion Channel
Amiloride-sensitive sodium channel subunit alpha Tclin Ion Channel
Amiloride-sensitive sodium channel subunit beta Tclin Ion Channel
Amiloride-sensitive sodium channel subunit gamma Tclin Ion Channel
Mineralocorticoid receptor Tclin Nuclear Receptor
Acid-sensing ion channel 1 Tchem Ion Channel
Name Description
amiloride A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
TCRDv4.6.0
DrugCentral Indication
DrugCentral
amiloride