Name Development Level Target Family
3-hydroxy-3-methylglutaryl-coenzyme A reductase Tclin Enzyme
Name Description
simvastatin A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
TCRDv4.6.0
DrugCentral Indication
DrugCentral
simvastatin