You are using an outdated browser. Please upgrade your browser to improve your experience.

frontotemporal dementia

Disease Summary
Associated Targets (1918)
Tbio

1405

Tchem

223

Tdark

213

Tclin

77


GARD Rare
Mondo Description Frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders, characterized by progressive changes in behavior, executive dysfunction and language impairment, as a result of degeneration of the medial prefrontal and frontoinsular cortices. Four clinical subtypes have been identified: semantic dementia, progressive non-fluent aphasia, behavioral variant FTD and right temporal lobar atrophy.
Uniprot Description A form of dementia characterized by pathologic finding of frontotemporal lobar degeneration, presenile dementia with behavioral changes, deterioration of cognitive capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In most cases, protein tau deposits are found in glial cells and/or neurons.
Disease Ontology Description A dementia characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language.
Mondo Term and Equivalent IDs
MONDO:0017276:  frontotemporal dementia
COHD:4043378: 
GARD:0008436: 
MESH:D057180: 
NCIT:C84719: 
Orphanet:282: 
UMLS:C0338451: 
UMLS:C0520716: