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malignant hyperthermia of anesthesia
Disease Summary
Associated Targets (6)
Tclin
5
Tbio
1
Mondo Description Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, to stresses such as vigorous exercise and heat.
Disease Ontology Description A muscle tissue disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature.
Mondo Term and Equivalent IDs
MONDO:0018493: malignant hyperthermia of anesthesia
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Counts of Target Development Levels for diseases known to be associated with this disease. If the disease has a valid DOID, targets known to be associated with all child diseases are aggregated. Click "Explore Associated Targets" to view more facets and details for the target list.
Description from Mondo Disease Ontology.
Description from Disease Ontology
DataSources which have contributed target associations to this disease, and the identifiers by which the disease is referenced.
DOID:8545
MESH:D008305
NCIT:C84869
OMIMPS:145600
Orphanet:423
SCTID:405501007
UMLS:C0024591
MONDO:0018493
High level summary of knowledge for a disease, including descriptions and datasource references.